PT  - JOURNAL ARTICLE
AU  - Mentzer, S J
AU  - Gromkowski, S H
AU  - Krensky, A M
AU  - Burakoff, S J
AU  - Martz, E
TI  - LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes.
DP  - 1985 Jul 01
TA  - The Journal of Immunology
PG  - 9--11
VI  - 135
IP  - 1
4099  - http://www.jimmunol.org/content/135/1/9.short
4100  - http://www.jimmunol.org/content/135/1/9.full
SO  - J. Immunol.1985 Jul 01; 135
AB  - We report here that MAb to human LFA-1 inhibit spontaneous homotypic adhesions of human B lymphocytes. This is, to our knowledge, the first report of a MAb that inhibits human homotypic intercellular adhesions for any cell type. LFA-1 has previously been recognized as a molecule capable of regulating specific immunologic adhesions between T lymphocytes and antigen-bearing target cells. The present findings show that the role of LFA-1 is not limited to adhesions initiated by specific immunologic recognition. The results indicate that the LFA-1 molecule is capable of regulating lymphocyte adhesions, possibly because it is a direct participant in adhesion formation.