PT  - JOURNAL ARTICLE
AU  - Petrie, H T
AU  - Klassen, L W
AU  - Kay, H D
TI  - Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes.
DP  - 1985 Jan 01
TA  - The Journal of Immunology
PG  - 230--234
VI  - 134
IP  - 1
4099  - http://www.jimmunol.org/content/134/1/230.short
4100  - http://www.jimmunol.org/content/134/1/230.full
SO  - J. Immunol.1985 Jan 01; 134
AB  - Peripheral blood granulocytes from normal healthy donors were found to reproducibly inhibit the cytolytic effector function of specifically sensitized cytotoxic T lymphocytes in vitro when co-incubated with these effector cells and target cells in 8 hr 51Cr release assays. Inhibition required intact granulocytes, was proportional to the number of granulocytes present, and was independent of granulocyte adherence, phagocytic function, and viability. Equivalent numbers of enriched normal or leukemic peripheral T lymphocytes did not cause inhibition of 51Cr release, and preincubation of granulocytes with effectors did not significantly alter viability or cytotoxic function. Because granulocytes can inhibit natural killer cell function in vitro, these data indicate that granulocytes can regulate diverse antigen-specific and spontaneous cytotoxic functions in vitro, suggesting that circulating granulocytes may have the potential for in vivo regulation of these cytotoxic effectors.