PT  - JOURNAL ARTICLE
AU  - Goodman, Michael G.
AU  - Weigle, William O.
TI  - T Cell Regulation of Polyclonal B Cell Responsiveness
DP  - 1979 Dec 01
TA  - The Journal of Immunology
PG  - 2484--2487
VI  - 123
IP  - 6
4099  - http://www.jimmunol.org/content/123/6/2484.short
4100  - http://www.jimmunol.org/content/123/6/2484.full
SO  - J. Immunol.1979 Dec 01; 123
AB  - In addition to the x-linked B cell maturation deficit previously reported in CBA/N mice, a functional T cell defect has now been observed. T lymphocyte regulation of the polyclonal PFC response was studied within the context of this x-linked immunodeficiency model. The ability of 1) B cells from (CBA/N × CBA/CaJ)F1, male mice to respond to nonspecific T cell helper signals and 2) T cells from NCF1 male mice to provide such signals was investigated under in vitro conditions by using bacterial lipopolysaccharide (LPS) as the polyclonal activator. B lymphocytes from both male and female NCF1 mice were receptive to T cell help rendered by NCF1 female T cells. Male T cells, however, were unable to augment polyclonal B cell responses of either NCF1 male or female B cells to LPS. Treatment with ATS + C reduced the polyclonal response of female but not male spleen cells to LPS. This deficit could not be overcome by the use of greater numbers of NCF1 male T cells. The observation that this deficiency in T cell regulation is not due to active suppression suggests that the results may be attributable to an intrinsic T cell defect.