RT Journal Article
SR Electronic
T1 Role of Self Carriers in the Immune Response and Tolerance
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 2447
OP 2450
VO 123
IS 6
A1 Jandinski, John J.
A1 Scott, David W.
YR 1979
UL http://www.jimmunol.org/content/123/6/2447.abstract
AB Previous studies indicated that T cells are required for tolerance induction by hapten-modified syngeneic spleen cells (TNP-SC) in vivo. The role of T cells in the maintenance of this unresponsive state has been examined herein. By three criteria—limiting dilution precursor analysis, removal of T cells by anti-Thy-1 + C, and direct mixing experiments—we show that T cells are required for the continued suppression of the B cell response to the T-independent antigen, TNP-POL. Suppressor cells can also be induced by TNP-teratoma cells, which lack detectable H-2 antigens. Both anti-Ly-1 + C and anti-Ly-2 + C treatment reversed suppression induced by TNP-SC. These results demonstrate that normal B cell reactivity is present in the spleens of mice rendered tolerant by haptenated self, but that Ly-1,2,3 or Ly-1 + Ly-2,3 suppressor T cells prevent their responsiveness.