RT Journal Article
SR Electronic
T1 Immunopotentiating Effects of Amphotericin B
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 2878
OP 2882
VO 123
IS 6
A1 Shirley, Sandra F.
A1 Little, J. Russell
YR 1979
UL http://www.jimmunol.org/content/123/6/2878.abstract
AB Contact sensitivity responses to dinitrofluorobenzene (DNFB) or oxazolone were enhanced by amphotericin B (AmB) administration. This adjuvant effect of AmB was documented in mice by ear thickness measurements, ear histology, and the 5-iodo-2′-deoxyuridine-125I ear assay. The optimum immunopotentiating effect of AmB required its simultaneous administration at the time of skin sensitization. AmB-induced adjuvant effects were also observed in adoptive transfer experiments in which syngeneic recipients of lymph node cells from animals sensitized with DNFB plus AmB gave stronger contact sensitivity responses than recipients of cells from mice sensitized with DNFB alone. AmB also interfered with tolerance induction by i.v. dinitrobenzene sulfonic acid, suggesting that its adjuvant effects involve inhibition of suppressor cells or their precursors.