PT  - JOURNAL ARTICLE
AU  - Mattes, M. Jules
AU  - Sharrow, Susan O.
AU  - Herberman, Ronald B.
AU  - Holden, Howard T.
TI  - Identification and Separation of Thy-1 Positive Mouse Spleen Cells Active in Natural Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity
DP  - 1979 Dec 01
TA  - The Journal of Immunology
PG  - 2851--2860
VI  - 123
IP  - 6
4099  - http://www.jimmunol.org/content/123/6/2851.short
4100  - http://www.jimmunol.org/content/123/6/2851.full
SO  - J. Immunol.1979 Dec 01; 123
AB  - The expression of the Thy-1 antigen on mouse spleen cells responsible for NK activity and ADCC was investigated by using a monoclonal IgM anti-Thy-1.2 antibody. Both C-mediated cytotoxicity and the fluorescence-activated cell sorter were used to fractionate cells. The effector cells were found to be heterogeneous in their expression of Thy-1. Effector cells from nude BALB/c mice were predominantly Thy-1 positive; some of the NK cells in CBA spleens appeared to be Thy-1 positive, but at least one-third of the lytic activity was due to Thy-1 negative cells. The effects of treatments on NK cytotoxicity and ADCC were very similar, supporting the hypothesis that the same cells mediate both activities.