PT - JOURNAL ARTICLE AU - Moriya, Naoki AU - Nagaoki, Takeshi AU - Okuda, Norihiko AU - Taniguchi, Noboru TI - Suppression of Adult B Cell Differentiation in Pokeweed Mitogen-Stimulated Cultures by Fc(IgG) Receptor-Negative T Cells from Cord Blood DP - 1979 Oct 01 TA - The Journal of Immunology PG - 1795--1798 VI - 123 IP - 4 4099 - http://www.jimmunol.org/content/123/4/1795.short 4100 - http://www.jimmunol.org/content/123/4/1795.full SO - J. Immunol.1979 Oct 01; 123 AB - Unfractionated T lymphocytes from cord blood suppressed adult B cell differentiation into immunoglobulin-producing cells in pokeweed mitogen-stimulated co-culture system. Cord blood T cells were fractionated into T cells bearing Fc receptors for IgG(Tγ cells) and T cells lacking Fc receptors for IgG(Tnon-γ cells) by rosette formation with ox erythrocytes coated by the IgG fraction of rabbit antisera followed by Ficoll-Hypaque gradient sedimentation. Tγ cells from cord blood, even though isolated after the interaction with immune complexes, showed no suppressor activity on adult B cell differentiation, whereas Tnon-γ cells exerted strong suppression to a similar extent to that by unfractionated cord T cells. The suppressor activity on B cell differentiation by Tnon-γ cells as well as by unfractionated T cells from cord blood was completely abrogated by irradiation with 2000 rads. These results indicated that, contrary to suppressor function found in adult T cells, the suppressor activity in cord T cells might be exerted by a T cell subset lacking Fc receptors for IgG(Tnon-γ cells).