PT  - JOURNAL ARTICLE
AU  - Capra, J. Donald
AU  - Ju, Shyr-Te
AU  - Nisonoff, Alfred
TI  - Structural Studies on Induced Antibodies with Defined Idiotypic Specificities
DP  - 1978 Sep 01
TA  - The Journal of Immunology
PG  - 953--957
VI  - 121
IP  - 3
4099  - http://www.jimmunol.org/content/121/3/953.short
4100  - http://www.jimmunol.org/content/121/3/953.full
SO  - J. Immunol.1978 Sep 01; 121
AB  - Previous studies in this series have been directed toward the elucidation of the heavy and light chain variable region structures of antibodies raised in A/J mice to the p-azophenylarsonate (Ar) hapten, certain of which bear a cross-reacting idiotype. The present study concerns an analysis of anti-Ar antibodies that arise in A/J mice suppressed for a cross-reacting idiotype. The results indicate that when an idiotype is suppressed and the animal subsequently hyperimmunized, the resultant antibodies are “deviated” into different V-region subgroups, both in the heavy and light polypeptide chains. The study presents the first primary structural analysis of a humoral immune response that has been manipulated by an idiotypic reagent.