PT  - JOURNAL ARTICLE
AU  - Shinohara, Nobukata
AU  - Lunney, Joan K.
AU  - Sachs, David H.
TI  - Sharing of Ia Antigens Between Species
DP  - 1978 Aug 01
TA  - The Journal of Immunology
PG  - 637--640
VI  - 121
IP  - 2
4099  - http://www.jimmunol.org/content/121/2/637.short
4100  - http://www.jimmunol.org/content/121/2/637.full
SO  - J. Immunol.1978 Aug 01; 121
AB  - A mouse alloantiserum B10.D2 anti-B10.BR (H-2d anti-H-2k) cross-reacted with rat lymphocyte surface glycoproteins with characteristics of Ia antigens. Sequential precipitation analysis on solubilized radiolabeled LEW rat lymphocyte antigens with this cross-reactive mouse alloantiserum and the rat alloantiserum BN anti-LEW (Ag-B3 anti-Ag-B1) revealed that the Ia-like antigen detected by the mouse alloantiserum also reacted with the rat anti-Ia antibodies. It was further shown that the rat alloantiserum also detected another set of Ia-like antigens that did not cross-react with the mouse alloantibody. Precipitation analysis with congenic rat strains confirmed that all Ia-like antigens precipitated by the rat alloantibody were encoded by Ag-B linked genes. Thus the shared Ia-like antigen must also be the product of Ag-B-linked gene(s) or be physically associated with such products. In addition, molecules bearing shared antigenic determinants were separable from at least some of the Ia-like antigens detected by the rat alloantiserum, possibly suggesting the existence of more than one sublocus coding for Ia antigens within the rat MHC.