RT Journal Article
SR Electronic
T1 Studies on the Cytophilic Properties of Human β<sub>2</sub> Microglobulin
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 997
OP 1000
VO 114
IS 3
A1 Anderson, Clark L.
A1 Kubo, Ralph T.
A1 Grey, Howard M.
YR 1975
UL http://www.jimmunol.org/content/114/3/997.abstract
AB Human β2microglobulin is cytophilic for mouse, rat, and to a lesser extent guinea pig lymphocytes and polymorphonuclear leukocytes but not for human, rabbit, chicken, frog, and turtle cells, nor for any mature erythrocytes tested. Mouse splenic lymphocytes bind 5- 7-fold more β2microglobulin than thymocytes although hydrocortisoneresistant thymocytes resemble spleen cells in this regard. The β2microglobulin binding by B and T cells in mouse spleen is similar. The structure responsible for β2 microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG.