PT  - JOURNAL ARTICLE
AU  - Levy, Michael H.
AU  - Wheelock, E. Frederick
TI  - Impaired Macrophage Function in Reiend Virus Leukemia: Restoration by Statolon
DP  - 1975 Mar 01
TA  - The Journal of Immunology
PG  - 962--965
VI  - 114
IP  - 3
4099  - http://www.jimmunol.org/content/114/3/962.short
4100  - http://www.jimmunol.org/content/114/3/962.full
SO  - J. Immunol.1975 Mar 01; 114
AB  - Phagocytic and migratory functions of peritoneal macrophages from Friend virus (FV) leukemic mice are significantly depressed as compared with normal controls. Leukemic macrophages exposed in vivo and in vitro to statolon, an extract of the mold Penicillium stoloniferum, shown previously to suppress FV erythroleukemia, regain normal function and release reduced amounts of FV. Statolon's in vivo restoration of leukemic macrophage function is paralleled by restoration of humoral immune competence. Statolon induces interferon in vitro but its effects on leukemic macrophages are probably direct, since restoration of macrophage function occurs at dosage levels far below those that induce interferon. These studies suggest that macrophages play an integral role in both the pathogenesis and the statolon-induced suppression of FV disease.