PT  - JOURNAL ARTICLE
AU  - Soter, Nicholas A.
AU  - Austen, K. Frank
AU  - Gigli, Irma
TI  - Inhibition by ɛ-Aminocaproic Acid of the Activation of the First Component of the Complement System
DP  - 1975 Mar 01
TA  - The Journal of Immunology
PG  - 928--932
VI  - 114
IP  - 3
4099  - http://www.jimmunol.org/content/114/3/928.short
4100  - http://www.jimmunol.org/content/114/3/928.full
SO  - J. Immunol.1975 Mar 01; 114
AB  - The influence of EACA on C1 in whole human serum and on C1 and C1̄ as isolated molecules was assessed hemolytically. There was selective inhibition of C1 without effect on the levels of C4, C2, C3, and C9 in whole human serum that was reversed by dialysis. EACA was found to inhibit the intrinsic activation of C1 without inhibiting the already active molecule. This was confirmed by the capacity of trypsin to uncover C1 activity in cellular intermediates formed by C1 treated with EACA that did not evolve in the absence of this extrinsic activating mechanism. Inasmuch as the trypsin-dependent recovery of C1 was incomplete, an effect on binding cannot be excluded.