PT  - JOURNAL ARTICLE
AU  - Rich, Robert R.
AU  - Rich, Susan Solliday
TI  - Biological Expressions of Lymphocyte Activation
DP  - 1975 Mar 01
TA  - The Journal of Immunology
PG  - 1112--1115
VI  - 114
IP  - 3
4099  - http://www.jimmunol.org/content/114/3/1112.short
4100  - http://www.jimmunol.org/content/114/3/1112.full
SO  - J. Immunol.1975 Mar 01; 114
AB  - Thymus-derived lymphocytes (T cells) from mouse spleen, activated in vitro or in vivo with concanavalin A (Con A), suppress proliferative responses of syngenic lymphocytes in mixed lymphocyte reactions (MLR). Replication in vitro was not required for expression of suppressor activity by Con A-activated cells and was blocked in MLR by treating suppressor cells with mitomycin C or irradiation. Kinetics of MLR responses and viability of cultures were not altered by addition of activated suppressor cells. The data are consistent with a direct inhibitory effect of suppressor T cells on antigen-induced DNA replication. These observations extend a model previously described for regulation of antibody synthesis by Con A-activated T cells to control of cell-mediated immune responses. This model should be particularly useful in further definition of regulatory T cell subpopulations, and in investigation of interactions and relationships between such populations.