RT Journal Article
SR Electronic
T1 Anti-Receptor Antibody
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 722
OP 727
VO 114
IS 2 Part 2
A1 Strayer, David S.
A1 Vitetta, Ellen S.
A1 Köhler, Heinz
YR 1975
UL http://www.jimmunol.org/content/114/2_Part_2/722.abstract
AB We have demonstrated a phosphorylcholine-binding protein in lysates from radioiodinated splenocytes of immunized mice. Immunoprecipitation with anti-receptor antibody of lysates from splenocytes obtained from animals undergoing a primary response or from mice immunized 4 to 6 months earlier with antigen demonstrated that this protein contained H and L chains. Therefore, we have isolated an antigen-specific receptor from the surface of spleen cells from both immunized and “memory” animals. This receptor Ig comprises approximately 10% of total cell surface Ig.