RT Journal Article
SR Electronic
T1 Preliminary Evidence for Cell-Mediated Immunity in Cross-Protection Among Group A Arboviruses
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 581
OP 584
VO 114
IS 2 Part 1
A1 Peck, Richard D.
A1 Brown, Arthur
A1 Wust, Carl J.
YR 1975
UL http://www.jimmunol.org/content/114/2_Part_1/581.abstract
AB Unfractionated and T cell-enriched populations from spleens of mice immunized with Sinbdis virus confer cross-protection against Semliki forest virus challenge in recipient mice. Both Group A viruses are serologically related, but not by tests for cross-neutralizing antibody. The protection in mice persisted for three consecutive cell passages in uninfected mice. The results suggest that cell-mediated immunity accounts for cross-protection.