RT Journal Article
SR Electronic
T1 Evolution of the Immune Response to Type III and VIII Pneumococcal Polysaccharides
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 98
OP 106
VO 110
IS 1
A1 Chen, Francis W.
A1 Strosberg, A. Donny
A1 Haber, Edgar
YR 1973
UL http://www.jimmunol.org/content/110/1/98.abstract
AB The variability of the immune response of 30 rabbits to the type III and of 40 rabbits to the type VIII pneumococci was studied. Sixty-seven out of 70 animals produced, at one time or another, antibodies of restricted electrophoretic mobility, but no general pattern could be defined. One animal produced a single antibody species throughout the six months of immunization. The homogeneity of this antibody population was evidenced by a unique amino acid sequence of the N-terminal part of the light chain. Only an interplay of several competing and cooperating mechanisms could account for the very diverse nature of the immune response observed in these experiments.