RT Journal Article SR Electronic T1 Observed Antibody Space: A Resource for Data Mining Next-Generation Sequencing of Antibody Repertoires JF The Journal of Immunology JO J. Immunol. FD American Association of Immunologists SP ji1800708 DO 10.4049/jimmunol.1800708 A1 Kovaltsuk, Aleksandr A1 Leem, Jinwoo A1 Kelm, Sebastian A1 Snowden, James A1 Deane, Charlotte M. A1 Krawczyk, Konrad YR 2018 UL http://www.jimmunol.org/content/early/2018/09/13/jimmunol.1800708.abstract AB Abs are immune system proteins that recognize noxious molecules for elimination. Their sequence diversity and binding versatility have made Abs the primary class of biopharmaceuticals. Recently, it has become possible to query their immense natural diversity using next-generation sequencing of Ig gene repertoires (Ig-seq). However, Ig-seq outputs are currently fragmented across repositories and tend to be presented as raw nucleotide reads, which means nontrivial effort is required to reuse the data for analysis. To address this issue, we have collected Ig-seq outputs from 55 studies, covering more than half a billion Ab sequences across diverse immune states, organisms (primarily human and mouse), and individuals. We have sorted, cleaned, annotated, translated, and numbered these sequences and make the data available via our Observed Antibody Space (OAS) resource at http://antibodymap.org. The data within OAS will be regularly updated with newly released Ig-seq datasets. We believe OAS will facilitate data mining of immune repertoires for improved understanding of the immune system and development of better biotherapeutics.