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Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents

Nhat-Tu Le, Yuichiro Takei, Yuki Izawa-Ishizawa, Kyung-Sun Heo, Hakjoo Lee, Alan V. Smrcka, Benjamin L. Miller, Kyung Ae Ko, Sara Ture, Craig Morrell, Keigi Fujiwara, Masashi Akaike and Jun-ichi Abe
J Immunol September 3, 2014, 1400571; DOI: https://doi.org/10.4049/jimmunol.1400571
Nhat-Tu Le
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Yuichiro Takei
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Yuki Izawa-Ishizawa
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Kyung-Sun Heo
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Hakjoo Lee
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Alan V. Smrcka
Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Benjamin L. Miller
Department of Dermatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642; and
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Kyung Ae Ko
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Sara Ture
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Craig Morrell
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Keigi Fujiwara
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Masashi Akaike
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8503, Japan
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Jun-ichi Abe
Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
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Data Supplement

Files in this Data Supplement:

  • Supplemental Material 1 (PDF)
  • Supplemental Figures 1 (PDF)
  • Supplemental Video 1 (MP4)
  • Supplemental Video 6 (MP4)
  • Supplemental Video 3 (MP4)
  • Supplemental Video 7 (MP4)
  • Supplemental Video 4 (MP4)
  • Supplemental Video 2 (MP4)
  • Supplemental Video 5 (MP4)

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Print ISSN 0022-1767        Online ISSN 1550-6606