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ANTIGEN RECOGNITION AND RESPONSES

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TCR Signal Strength and Antigen Affinity Regulate CD8⁺ Memory T Cells
Sabrina Solouki, Weishan Huang, Jessica Elmore, Candice Limper, Fei Huang and Avery August

J Immunol August 5, 2020, ji1901167; DOI: https://doi.org/10.4049/jimmunol.1901167
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Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4⁺ T Cells
Haiyin Liu, Kayla R. Wilson, Patrick Schriek, Christophe Macri, Annabelle B. Blum, Lauren Francis, Melanie Heinlein, Champa Nataraja, James Harris, Sarah A. Jones, Daniel H. D. Gray, Jose A. Villadangos and Justine D. Mintern

J Immunol August 3, 2020, ji1901328; DOI: https://doi.org/10.4049/jimmunol.1901328
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Conditional Silencing of H-2D^b Class I Molecule Expression Modulates the Protective and Pathogenic Kinetics of Virus-Antigen–Specific CD8 T Cell Responses during Theiler's Virus Infection
Zachariah P. Tritz, Robin C. Orozco, Courtney S. Malo, Katayoun Ayasoufi, Cori E. Fain, Roman H. Khadka, Emma N. Goddery, Lila T. Yokanovich, Megan L. Settell, Michael J. Hansen, Fang Jin, Kevin D. Pavelko, Larry R. Pease and Aaron J. Johnson

J Immunol July 31, 2020, ji2000340; DOI: https://doi.org/10.4049/jimmunol.2000340

AUTOIMMUNITY

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Peripheral Tolerance Checkpoints Imposed by Ubiquitous Antigen Expression Limit Antigen-Specific B Cell Responses under Strongly Immunogenic Conditions
Jeremy F. Brooks, Peter R. Murphy, James E. M. Barber, James W. Wells and Raymond J. Steptoe

J Immunol July 24, 2020, ji2000377; DOI: https://doi.org/10.4049/jimmunol.2000377

BRIEF REVIEWS

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COVID-19: Complement, Coagulation, and Collateral Damage
Martin W. Lo, Claudia Kemper and Trent M. Woodruff

J Immunol July 22, 2020, ji2000644; DOI: https://doi.org/10.4049/jimmunol.2000644
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SARS-CoV-2 as a Factor to Disbalance the Renin–Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production
Rafael Franco, Rafael Rivas-Santisteban, Joan Serrano-Marín, Ana I. Rodríguez-Pérez, José L. Labandeira-García and Gemma Navarro

J Immunol July 17, 2020, ji2000642; DOI: https://doi.org/10.4049/jimmunol.2000642

CLINICAL AND HUMAN IMMUNOLOGY

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A Point Mutation Creating a 3′ Splice Site in C8A Is a Predominant Cause of C8α-γ Deficiency in African Americans
Peter Densen, Laynez Ackermann, Leslie Saucedo, Julio E. Figueroa, Zhi-hai Si and Conrad Martin Stoltzfus

J Immunol August 7, 2020, ji2000272; DOI: https://doi.org/10.4049/jimmunol.2000272
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Ascorbic Acid Promotes KIR Demethylation during Early NK Cell Differentiation
Cheng-Ying Wu, Bin Zhang, Hansol Kim, Stephen K. Anderson, Jeffrey S. Miller and Frank Cichocki

J Immunol August 5, 2020, ji2000212; DOI: https://doi.org/10.4049/jimmunol.2000212
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Landscape of T Follicular Helper Cell Dynamics in Human Germinal Centers
Emmanuel Donnadieu, Kerstin Bianca Reisinger, Sonja Scharf, Yvonne Michel, Julia Bein, Susanne Hansen, Andreas G. Loth, Nadine Flinner, Sylvia Hartmann and Martin-Leo Hansmann

J Immunol July 22, 2020, ji1901475; DOI: https://doi.org/10.4049/jimmunol.1901475
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Chaperone-Mediated Autophagy Suppresses Apoptosis via Regulation of the Unfolded Protein Response during Chronic Obstructive Pulmonary Disease Pathogenesis
Yusuke Hosaka, Jun Araya, Yu Fujita, Tsukasa Kadota, Kazuya Tsubouchi, Masahiro Yoshida, Shunsuke Minagawa, Hiromichi Hara, Hironori Kawamoto, Naoaki Watanabe, Akihiko Ito, Akihiro Ichikawa, Nayuta Saito, Keitaro Okuda, Junko Watanabe, Daisuke Takekoshi, Hirofumi Utsumi, Mitsuo Hashimoto, Hiroshi Wakui, Saburo Ito, Takanori Numata, Shohei Mori, Hideki Matsudaira, Jun Hirano, Takashi Ohtsuka, Katsutoshi Nakayama and Kazuyoshi Kuwano

J Immunol July 22, 2020, ji2000132; DOI: https://doi.org/10.4049/jimmunol.2000132

CORRECTIONS

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Correction: Bcl2L12 Contributes to Th2-Biased Inflammation in the Intestinal Mucosa by Regulating CD4⁺ T Cell Activities
Mao-Gang Li, Xiao-Yu Liu, Zhi-Qiang Liu, Jing-Yi Hong, Jiang-Qi Liu, Cai-Jie Zhou, Tian-Yong Hu, Xiao-Jun Xiao, Pi-Xin Ran, Peng-Yuan Zheng, Zhi-Gang Liu and Ping-Chang Yang

J Immunol July 29, 2020, ji2000804; DOI: https://doi.org/10.4049/jimmunol.2000804

IMMUNE REGULATION

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A Novel Cochlioquinone Derivative, CoB1, Regulates Autophagy in Pseudomonas aeruginosa Infection through the PAK1/Akt1/mTOR Signaling Pathway
Pengcheng Zhu, Huimin Bu, Shirui Tan, Jinjuan Liu, Bo Yuan, Guokai Dong, Meng Wang, Yuji Jiang, Hong Zhu, Hui Li, Zhenjun Li, Jihong Jiang, Min Wu and Rongpeng Li

J Immunol August 3, 2020, ji1901346; DOI: https://doi.org/10.4049/jimmunol.1901346
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Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22
Mudan Zhang, Ming Fu, Miaomiao Li, Huimin Hu, Sitang Gong and Qinxue Hu

J Immunol July 22, 2020, ji2000418; DOI: https://doi.org/10.4049/jimmunol.2000418
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IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells
Mohamed Benhammadi, Justine Mathé, Maude Dumont-Lagacé, Koichi S. Kobayashi, Louis Gaboury, Sylvie Brochu and Claude Perreault

J Immunol July 20, 2020, ji2000225; DOI: https://doi.org/10.4049/jimmunol.2000225

IMMUNE SYSTEM DEVELOPMENT

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Control of GM-CSF–Dependent Dendritic Cell Differentiation and Maturation by DEF6 and SWAP-70
Jelena Popović, Inga Wellstein, Alessandra Pernis, Rolf Jessberger and Carlos Ocaña-Morgner

J Immunol July 24, 2020, ji2000020; DOI: https://doi.org/10.4049/jimmunol.2000020

IMMUNOGENETICS

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Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease
Kirsten M. Anderson, Danillo G. Augusto, Ravi Dandekar, Hengameh Shams, Chao Zhao, Tasneem Yusufali, Gonzalo Montero-Martín, Wesley M. Marin, Neda Nemat-Gorgani, Lisa E. Creary, Stacy Caillier, Mohammad R. K. Mofrad, Peter Parham, Marcelo Fernández-Viña, Jorge R. Oksenberg, Paul J. Norman and Jill A. Hollenbach

J Immunol July 29, 2020, ji2000144; DOI: https://doi.org/10.4049/jimmunol.2000144
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An Ig γ Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E ε4 Genotype
Janardan P. Pandey, Jan Olsson, Bodil Weidung, Ronald T. Kothera, Anders Johansson, Sture Eriksson, Göran Hallmans, Fredrik Elgh and Hugo Lövheim

J Immunol July 24, 2020, ji2000351; DOI: https://doi.org/10.4049/jimmunol.2000351

IMMUNOTHERAPY AND VACCINES

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Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions
Satoru Watanabe, Masayuki Fujino, Yohei Saito, Nursarat Ahmed, Hirotaka Sato, Chie Sugimoto, Tomotaka Okamura, Kenichi Hanaki, Emi E. Nakayama, Tatsuo Shioda, Kouji Matsushima, Aftab A. Ansari, Francois Villinger and Kazuyasu Mori

J Immunol August 3, 2020, ji1901431; DOI: https://doi.org/10.4049/jimmunol.1901431
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Insights into the Mechanism of Action of Highly Diluted Biologics
Sergey A. Tarasov, Evgeniy A. Gorbunov, Elena S. Don, Alexandra G. Emelyanova, Alexander L. Kovalchuk, Naveena Yanamala, A. Sylvia S. Schleker, Judith Klein-Seetharaman, Reno Groenestein, Jean-Pierre Tafani, Peter van der Meide and Oleg I. Epstein

J Immunol July 29, 2020, ji2000098; DOI: https://doi.org/10.4049/jimmunol.2000098

INFECTIOUS DISEASE AND HOST RESPONSE

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Complement Receptor 3 Contributes to the Sexual Dimorphism in Neutrophil Killing of Staphylococcus aureus
Srijana Pokhrel, Kathleen D. Triplett, Seth M. Daly, Jason A. Joyner, Geetanjali Sharma, Helen J. Hathaway, Eric R. Prossnitz and Pamela R. Hall

J Immunol August 7, 2020, ji2000545; DOI: https://doi.org/10.4049/jimmunol.2000545
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Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein Suppresses Type I IFN Expression by Impeding HSP70-Dependent Activation of IRF3 Kinase IKKε
Lok-Yin Roy Wong, Zi-Wei Ye, Pak-Yin Lui, Xuyang Zheng, Shuofeng Yuan, Lin Zhu, Sin-Yee Fung, Kit-San Yuen, Kam-Leung Siu, Man-Lung Yeung, Zongwei Cai, Patrick Chiu-Yat Woo, Kwok-Yung Yuen, Chi-Ping Chan and Dong-Yan Jin

J Immunol August 3, 2020, ji1901489; DOI: https://doi.org/10.4049/jimmunol.1901489
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Identification of a Protective Leishmania Antigen Dihydrolipoyl Dehydrogenase and Its Responding CD4⁺ T Cells at Clonal Level
Zhirong Mou, Aida F. Barazandeh, Hiroshi Hamana, Hiroyuki Kishi, Xiaoping Zhang, Ping Jia, Nnamdi Ikeogu, Chukwunonso Onyilagha, Gaurav Gupta and Jude E. Uzonna

J Immunol July 29, 2020, ji2000338; DOI: https://doi.org/10.4049/jimmunol.2000338

INNATE IMMUNITY AND INFLAMMATION

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Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR
Xingjiang Mu, Peng Wang, Xiaohong Wang, Yutian Li, Hongyan Zhao, Qianqian Li, Kobina Essandoh, Shan Deng, Tianqing Peng and Guo-Chang Fan

J Immunol August 7, 2020, ji2000440; DOI: https://doi.org/10.4049/jimmunol.2000440
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Complement Activation and Thrombin Generation by MBL Bound to β2-Glycoprotein I
Paolo Durigutto, Paolo Macor, Nicola Pozzi, Chiara Agostinis, Fleur Bossi, Pier Luigi Meroni, Claudia Grossi, Maria O. Borghi, William Planer, Peter Garred and Francesco Tedesco

J Immunol August 5, 2020, ji2000570; DOI: https://doi.org/10.4049/jimmunol.2000570
Open Access
B Lymphocyte–Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury
Author Choice Article

Akimichi Inaba, Zewen K. Tuong, Alexandra M. Riding, Rebeccah J. Mathews, Jack L. Martin, Kourosh Saeb-Parsy and Menna R. Clatworthy

J Immunol July 31, 2020, ji2000454; DOI: https://doi.org/10.4049/jimmunol.2000454
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Disease Risk–Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor–Induced Outcomes in Human Macrophages
Matija Hedl, Rui Sun and Clara Abraham

J Immunol July 31, 2020, ji1901112; DOI: https://doi.org/10.4049/jimmunol.1901112
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NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury
Homare Ito, Hiroaki Kimura, Tadayoshi Karasawa, Shu Hisata, Ai Sadatomo, Yoshiyuki Inoue, Naoya Yamada, Emi Aizawa, Erika Hishida, Ryo Kamata, Takanori Komada, Sachiko Watanabe, Tadashi Kasahara, Takuji Suzuki, Hisanaga Horie, Joji Kitayama, Naohiro Sata, Kazuyo Yamaji-Kegan and Masafumi Takahashi

J Immunol July 29, 2020, ji2000217; DOI: https://doi.org/10.4049/jimmunol.2000217
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ArhGAP15, a RacGAP, Acts as a Temporal Signaling Regulator of Mac-1 Affinity in Sterile Inflammation
Andreas Margraf, Anika Cappenberg, Eduardo Vadillo, Nadine Ludwig, Katharina Thomas, Katharina Körner, Lisa Zondler, Jan Rossaint, Giulia Germena, Emilio Hirsch and Alexander Zarbock

J Immunol July 27, 2020, ji2000047; DOI: https://doi.org/10.4049/jimmunol.2000047

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase
Alessandra Zarantonello, Jessy Presumey, Léa Simoni, Esra Yalcin, Rachel Fox, Annette Hansen, Heidi Gytz Olesen, Steffen Thiel, Matthew B. Johnson, Beth Stevens, Nick Stub Laursen, Michael C. Carroll and Gregers R. Andersen

J Immunol August 7, 2020, ji2000528; DOI: https://doi.org/10.4049/jimmunol.2000528
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ARID1a Associates with Lymphoid-Restricted Transcription Factors and Has an Essential Role in T Cell Development
Audrey Astori, Johanna Tingvall-Gustafsson, Jacob Kuruvilla, Etienne Coyaud, Estelle M. N. Laurent, Maria Sunnerhagen, Josefine Åhsberg, Jonas Ungerbäck, Tobias Strid, Mikael Sigvardsson, Brian Raught and Rajesh Somasundaram

J Immunol August 3, 2020, ji1900959; DOI: https://doi.org/10.4049/jimmunol.1900959

TRANSPLANTATION

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Posttransplant Cyclophosphamide and Antithymocyte Globulin versus Posttransplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis for Peripheral Blood Stem Cell Haploidentical Transplants: Comparison of T Cell and NK Effector Reconstitution
Dhon Roméo Makanga, Thierry Guillaume, Catherine Willem, Nolwenn Legrand, Katia Gagne, Anne Cesbron, Ketevan Gendzekhadze, Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Marie C. Béné, Patrice Chevallier and Christelle Retière

J Immunol August 3, 2020, ji2000578; DOI: https://doi.org/10.4049/jimmunol.2000578
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Blockade of the G-CSF Receptor Is Protective in a Mouse Model of Renal Ischemia–Reperfusion Injury
Jennifer L. McRae, Ingela B. Vikstrom, Anjan K. Bongoni, Evelyn J. Salvaris, Nella Fisicaro, Milica Ng, Monther Alhamdoosh, Adriana Baz Morelli, Peter J. Cowan and Martin J. Pearse

J Immunol July 27, 2020, ji2000390; DOI: https://doi.org/10.4049/jimmunol.2000390

TUMOR IMMUNOLOGY

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Adoptive T Cell Therapy with IL-12–Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity
Christopher G. Tucker, Jason S. Mitchell, Tijana Martinov, Brandon J. Burbach, Lalit K. Beura, Joseph C. Wilson, Alexander J. Dwyer, Lovejot M. Singh, Matthew F. Mescher and Brian T. Fife

J Immunol July 31, 2020, ji2000007; DOI: https://doi.org/10.4049/jimmunol.2000007
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Collagen Density Modulates the Immunosuppressive Functions of Macrophages
Anne Mette H. Larsen, Dorota E. Kuczek, Adrija Kalvisa, Majken S. Siersbæk, Marie-Louise Thorseth, Astrid Z. Johansen, Marco Carretta, Lars Grøntved, Ole Vang and Daniel H. Madsen

J Immunol July 27, 2020, ji1900789; DOI: https://doi.org/10.4049/jimmunol.1900789

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ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

BRIEF REVIEWS

CLINICAL AND HUMAN IMMUNOLOGY

CORRECTIONS

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TRANSPLANTATION

TUMOR IMMUNOLOGY

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