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ALLERGY AND OTHER HYPERSENSITIVITIES

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Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation
Masayuki Kitajima, Masato Kubo, Steven F. Ziegler and Harumi Suzuki

J Immunol May 22, 2020, ji1900758; DOI: https://doi.org/10.4049/jimmunol.1900758
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Group 2 Innate Lymphoid Cells Promote Development of T Follicular Helper Cells and Initiate Allergic Sensitization to Peanuts
James W. Krempski, Takao Kobayashi, Koji Iijima, Andrew N. McKenzie and Hirohito Kita

J Immunol May 4, 2020, ji2000029; DOI: https://doi.org/10.4049/jimmunol.2000029
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Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation
Kazuki Yoshida, Masa-aki Ito, Naoko Sato, Kosuke Obayashi, Kimiko Yamamoto, Schuichi Koizumi, Satoshi Tanaka, Kazuyuki Furuta and Isao Matsuoka

J Immunol May 1, 2020, ji1900954; DOI: https://doi.org/10.4049/jimmunol.1900954
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Secreted Phospholipase A₂ Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung
Herbert Luke Ogden, Ying Lai, James D. Nolin, Dowon An, Charles W. Frevert, Michael H. Gelb, William A. Altemeier and Teal S. Hallstrand

J Immunol April 27, 2020, ji2000102; DOI: https://doi.org/10.4049/jimmunol.2000102

ANTIGEN RECOGNITION AND RESPONSES

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The Impact of MHC Class I Dose on Development and Maintenance of the Polyclonal Naive CD8⁺ T Cell Repertoire
Xavier Y. X. Sng, Jasmine Li, Pirooz Zareie, Lisa M. Assmus, Jason K. C. Lee, Claerwen M. Jones, Stephen J. Turner, Stephen R. Daley, Kylie M. Quinn and Nicole L. La Gruta

J Immunol April 27, 2020, ji2000081; DOI: https://doi.org/10.4049/jimmunol.2000081

AUTOIMMUNITY

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Costimulation Blockade Disrupts CD4⁺ T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes
Martin Eichmann, Roman Baptista, Richard J. Ellis, Susanne Heck, Mark Peakman and Craig A. Beam

J Immunol May 13, 2020, ji1901439; DOI: https://doi.org/10.4049/jimmunol.1901439
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Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease
Manoj Thapa, Dana Tedesco, Sanjeev Gumber, Elizabeth J. Elrod, Jin-Hwan Han, William H. Kitchens, Joseph F. Magliocca, Andrew B. Adams and Arash Grakoui

J Immunol April 24, 2020, ji1900391; DOI: https://doi.org/10.4049/jimmunol.1900391

BRIEF REVIEWS

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COVID-19 as an Acute Inflammatory Disease
Rose H. Manjili, Melika Zarei, Mehran Habibi and Masoud H. Manjili

J Immunol May 18, 2020, ji2000413; DOI: https://doi.org/10.4049/jimmunol.2000413

CLINICAL AND HUMAN IMMUNOLOGY

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Expansion of Group 2 Innate Lymphoid Cells in Patients with End-Stage Renal Disease and Their Clinical Significance
Gao-Yu Liu, Xiao-Hui Deng, Xing Li, Ying-Jiao Cao, Yan-Fang Xing, Pan Zhou, Ai-Hua Lei, Quan Yang, Kai Deng, Hui Zhang and Jie Zhou

J Immunol May 22, 2020, ji1901095; DOI: https://doi.org/10.4049/jimmunol.1901095
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Cord Blood Low-Density Granulocytes Correspond to an Immature Granulocytic Subset with Low Expression of S100A12
Toni Weinhage, Tristan Kölsche, Esther Rieger-Fackeldey, Ralf Schmitz, Anne-Charlotte Antoni, Martina Ahlmann, Dirk Foell and Helmut Wittkowski

J Immunol May 22, 2020, ji1901308; DOI: https://doi.org/10.4049/jimmunol.1901308
Open Access
Opsonization-Enhanced Antigen Presentation by MR1 Activates Rapid Polyfunctional MAIT Cell Responses Acting as an Effector Arm of Humoral Antibacterial Immunity
Author Choice Article

Caroline Boulouis, Jean-Baptiste Gorin, Joana Dias, Peter Bergman, Edwin Leeansyah and Johan K. Sandberg

J Immunol May 20, 2020, ji2000003; DOI: https://doi.org/10.4049/jimmunol.2000003
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Human Term Pregnancy Decidual NK Cells Generate Distinct Cytotoxic Responses
Ricardo de Mendonça Vieira, Ava Meagher, Ângela C. Crespo, Sarika K. Kshirsagar, Vidya Iyer, Errol R. Norwitz, Jack L. Strominger and Tamara Tilburgs

J Immunol May 6, 2020, ji1901435; DOI: https://doi.org/10.4049/jimmunol.1901435
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GPA33: A Marker to Identify Stable Human Regulatory T Cells
Rianne Opstelten, Sander de Kivit, Manon C. Slot, Maartje van den Biggelaar, Dorota Iwaszkiewicz-Grześ, Mateusz Gliwiński, Andrew M. Scott, Bianca Blom, Piotr Trzonkowski, Jannie Borst, Eloy Cuadrado and Derk Amsen

J Immunol May 4, 2020, ji1901250; DOI: https://doi.org/10.4049/jimmunol.1901250

CUTTING EDGE

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Cutting Edge: STAT1-Mediated Epigenetic Control of Rsad2 Promotes Clonal Expansion of Antiviral NK Cells
Gabriela M. Wiedemann, Clair D. Geary, Colleen M. Lau and Joseph C. Sun

J Immunol May 27, 2020, ji2000086; DOI: https://doi.org/10.4049/jimmunol.2000086
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Cutting Edge: ST8Sia6-Generated α-2,8-Disialic Acids Mitigate Hyperglycemia in Multiple Low-Dose Streptozotocin–Induced Diabetes
Paul J. Belmonte, Michael J. Shapiro, Matthew J. Rajcula, Shaylene A. McCue and Virginia Smith Shapiro

J Immunol April 29, 2020, ji2000023; DOI: https://doi.org/10.4049/jimmunol.2000023

IMMUNE REGULATION

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Immune Complex–Driven Generation of Human Macrophages with Anti-Inflammatory and Growth-Promoting Activity
Elizabeth Dalby, Stephen M. Christensen, Jingya Wang, Kajal Hamidzadeh, Prabha Chandrasekaran, V. Keith Hughitt, Wagner Luiz Tafuri, Rosa Maria Esteves Arantes, Ismael Alves Rodrigues, Ronald Herbst, Najib M. El-Sayed, Gary P. Sims and David M. Mosser

J Immunol May 20, 2020, ji1901382; DOI: https://doi.org/10.4049/jimmunol.1901382
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Maintenance of Germinal Center B Cells by Caspase-9 through Promotion of Apoptosis and Inhibition of Necroptosis
Jingting Zhang, Srikanth Kodali, Min Chen and Jin Wang

J Immunol May 20, 2020, ji2000359; DOI: https://doi.org/10.4049/jimmunol.2000359
Open Access
Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation
Author Choice Article

Anne-Katrien Stark, Elizabeth C. M. Davenport, Daniel T. Patton, Cheryl L. Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A. Garden and Klaus Okkenhaug

J Immunol May 15, 2020, ji2000043; DOI: https://doi.org/10.4049/jimmunol.2000043
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Inhibition of Glycolysis in Pathogenic T_H17 Cells through Targeting a miR-21–Peli1–c-Rel Pathway Prevents Autoimmunity
Rong Qiu, Xiang Yu, Li Wang, Zhijun Han, Chao Yao, Yange Cui, Guojun Hou, Dai Dai, Wenfei Jin and Nan Shen

J Immunol May 15, 2020, ji2000060; DOI: https://doi.org/10.4049/jimmunol.2000060
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Tracing Self-Reactive B Cells in Normal Mice
Takuya Nojima, Alexander E. Reynolds, Daisuke Kitamura, Garnett Kelsoe and Masayuki Kuraoka

J Immunol May 15, 2020, ji1901015; DOI: https://doi.org/10.4049/jimmunol.1901015
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The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells
Hilary R. Keller, Hye Kyung Kim, Yuna Jo, Ronald E. Gress, Changwan Hong and Jung-Hyun Park

J Immunol May 11, 2020, ji1901276; DOI: https://doi.org/10.4049/jimmunol.1901276
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Intravenous Infusion of Cortisol, Adrenaline, or Noradrenaline Alters Porcine Immune Cell Numbers and Promotes Innate over Adaptive Immune Functionality
Lena Reiske, Sonja Schmucker, Birgit Pfaffinger, Ulrike Weiler, Julia Steuber and Volker Stefanski

J Immunol May 11, 2020, ji2000269; DOI: https://doi.org/10.4049/jimmunol.2000269
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Rapid Death of Follicular B Cells and Burkitt Lymphoma Cells Effectuated by Xbp1s
Yi-Ting Chen and John T. Kung

J Immunol May 6, 2020, ji2000172; DOI: https://doi.org/10.4049/jimmunol.2000172
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An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3
Ling Xu, Dandan Yu, Li Peng, Yong Wu, Yu Fan, Tianle Gu, Yu-Lin Yao, Jin Zhong, Xinwen Chen and Yong-Gang Yao

J Immunol May 6, 2020, ji1901320; DOI: https://doi.org/10.4049/jimmunol.1901320
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Endogenous CD83 Expression in CD4⁺ Conventional T Cells Controls Inflammatory Immune Responses
Katarina Liedtke, Christina Alter, Anne Günther, Nadine Hövelmeyer, Robert Klopfleisch, Ronald Naumann, F. Thomas Wunderlich, Jan Buer, Astrid M. Westendorf and Wiebke Hansen

J Immunol April 27, 2020, ji2000042; DOI: https://doi.org/10.4049/jimmunol.2000042
Open Access
Genome-Wide DNA Methylation and RNA Analysis Reveal Potential Mechanism of Resistance to Streptococcus agalactiae in GIFT Strain of Nile Tilapia (Oreochromis niloticus)
Author Choice Article

Qiaomu Hu, Qiuwei Ao, Yun Tan, Xi Gan, Yongju Luo and Jiajie Zhu

J Immunol April 24, 2020, ji1901496; DOI: https://doi.org/10.4049/jimmunol.1901496
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TGF-β and IL-15 Synergize through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1–like Phenotype
Lindsey G. Hawke, Brandon Z. Mitchell and Mark L. Ormiston

J Immunol April 24, 2020, ji1900866; DOI: https://doi.org/10.4049/jimmunol.1900866

IMMUNE SYSTEM DEVELOPMENT

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Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity
Cindy Audiger, Adrien Fois, Alyssa L. Thomas, Edith Janssen, Martin Pelletier and Sylvie Lesage

J Immunol May 27, 2020, ji1900970; DOI: https://doi.org/10.4049/jimmunol.1900970
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MHC-Independent Thymic Selection of CD4 and CD8 Coreceptor Negative αβ T Cells
Roxanne Collin, Félix Lombard-Vadnais, Erin E. Hillhouse, Marie-Ève Lebel, Geneviève Chabot-Roy, Heather J. Melichar and Sylvie Lesage

J Immunol May 20, 2020, ji2000156; DOI: https://doi.org/10.4049/jimmunol.2000156
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UHRF1 Controls Thymocyte Fate Decisions through the Epigenetic Regulation of EGR1 Expression
Yiwen Zhang, Yingshi Chen, Rong Ma, Yawen Jiang, Jun Liu, Yingtong Lin, Siqi Chen, Mengying Xia, Fan Zou, Junsong Zhang, Ting Pan, Lie Wang, Lai Wei and Hui Zhang

J Immunol May 1, 2020, ji1901471; DOI: https://doi.org/10.4049/jimmunol.1901471
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Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes
Michihiro Kobayashi, Yang Lin, Akansha Mishra, Chris Shelly, Rui Gao, Colton W. Reeh, Paul Zhiping Wang, Rongwen Xi, Yunlong Liu, Pamela Wenzel, Eliver Ghosn, Yan Liu and Momoko Yoshimoto

J Immunol April 29, 2020, ji2000030; DOI: https://doi.org/10.4049/jimmunol.2000030

IMMUNOGENETICS

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Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies
Peter van Balen, Michel G. D. Kester, Wendy de Klerk, Pietro Crivello, Esteban Arrieta-Bolaños, Arnoud H. de Ru, Inge Jedema, Yassene Mohammed, Mirjam H. M. Heemskerk, Katharina Fleischhauer, Peter A. van Veelen and J. H. Frederik Falkenburg

J Immunol April 29, 2020, ji2000192; DOI: https://doi.org/10.4049/jimmunol.2000192

IMMUNOTHERAPY AND VACCINES

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Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae
Author Choice Article

Sunita Gulati, Ian C. Schoenhofen, Theresa Lindhout-Djukic, Melissa J. Schur, Corinna S. Landig, Sudeshna Saha, Lingquan Deng, Lisa A. Lewis, Bo Zheng, Ajit Varki and Sanjay Ram

J Immunol May 20, 2020, ji1901398; DOI: https://doi.org/10.4049/jimmunol.1901398
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CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection
Althea Campuzano, Hao Zhang, Gary R. Ostroff, Lucas dos Santos Dias, Marcel Wüthrich, Bruce S. Klein, Jieh-Juen Yu, Humberto H. Lara, Jose L. Lopez-Ribot and Chiung-Yu Hung

J Immunol May 1, 2020, ji1900793; DOI: https://doi.org/10.4049/jimmunol.1900793

INFECTIOUS DISEASE AND HOST RESPONSE

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An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes
Sabrina Helmold Hait, Christopher James Hogge, Mohammad Arif Rahman, Eun-Ju Ko, Ruth Hunegnaw, Zuena Mushtaq, Gospel Enyindah-Asonye, Tanya Hoang, Lisa M. Miller Jenkins, Ettore Appella, Daniel H. Appella and Marjorie Robert-Guroff

J Immunol May 11, 2020, ji2000165; DOI: https://doi.org/10.4049/jimmunol.2000165
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CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation
Fahmida Alam, Ayushi Singh, Valeria Flores-Malavet, Stewart Sell, Andrea M. Cooper, Susan L. Swain, K. Kai McKinstry and Tara M. Strutt

J Immunol May 6, 2020, ji2000205; DOI: https://doi.org/10.4049/jimmunol.2000205

INNATE IMMUNITY AND INFLAMMATION

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CCL17 in Inflammation and Pain
Kevin M.-C. Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J. Fleetwood, Gary P. Anderson, Christian Ellson, Maria Feeney, Louise K. Modis, Julia E. Smith, John A. Hamilton and Andrew Cook

J Immunol May 27, 2020, ji2000315; DOI: https://doi.org/10.4049/jimmunol.2000315
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Requirement of Complement C6 for Intact Innate Immune Responses in Mice
Fatemeh Fattahi, Jamison J. Grailer, Michella Parlett, Hope Lu, Elizabeth A. Malan, Elizabeth Abe, Mark W. Russell, Lynn M. Frydrych, Matthew J. Delano, Firas S. Zetoune and Peter A. Ward

J Immunol May 22, 2020, ji1900801; DOI: https://doi.org/10.4049/jimmunol.1900801
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Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor
Langni Liu, Katherine E. Fahy, Azeezat A. Awoyemi, Pariksha Thapa, Lisa E. Kelly, Jay Chen, Ji C. Bihl, David R. Cool, Yanfang Chen, Christine M. Rapp, R. Michael Johnson and Jeffrey B. Travers

J Immunol May 20, 2020, ji1901393; DOI: https://doi.org/10.4049/jimmunol.1901393
Open Access
Direct Antiviral Activity of IFN-Stimulated Genes Is Responsible for Resistance to Paramyxoviruses in ISG15-Deficient Cells
Author Choice Article

David Holthaus, Andri Vasou, Connor G. G. Bamford, Jelena Andrejeva, Christina Paulus, Richard E. Randall, John McLauchlan and David J. Hughes

J Immunol May 18, 2020, ji1901472; DOI: https://doi.org/10.4049/jimmunol.1901472
Open Access
Activation of CB₁R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury
Author Choice Article

Jérémie Joffre, Che-Chung Yeh, Erika Wong, Mayuri Thete, Fengyun Xu, Ivana Zlatanova, Elliot Lloyd, Lester Kobzik, Matthieu Legrand and Judith Hellman

J Immunol May 18, 2020, ji2000213; DOI: https://doi.org/10.4049/jimmunol.2000213
Open Access
TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection
Author Choice Article

Caitlyn T. Hoffpauir, Samantha L. Bell, Kelsi O. West, Tao Jing, Allison R. Wagner, Sylvia Torres-Odio, Jeffery S. Cox, A. Phillip West, Pingwei Li, Kristin L. Patrick and Robert O. Watson

J Immunol May 13, 2020, ji1901511; DOI: https://doi.org/10.4049/jimmunol.1901511
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SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity
Peidian Shi, Yanyu Guo, Yanxin Su, Min Zhu, Yali Fu, Heng Chi, Jiaqi Wu and Jinhai Huang

J Immunol May 11, 2020, ji2000053; DOI: https://doi.org/10.4049/jimmunol.2000053
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IL-1R Regulates Disease Tolerance and Cachexia in Toxoplasma gondii Infection
Stephanie J. Melchor, Claire M. Saunders, Imani Sanders, Jessica A. Hatter, Kari A. Byrnes, Sheryl Coutermarsh-Ott and Sarah E. Ewald

J Immunol April 29, 2020, ji2000159; DOI: https://doi.org/10.4049/jimmunol.2000159

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells
Sarah J. Meyer, Alexander Böser, Marina A. Korn, Claudia Koller, Barbara Bertocci, Lena Reimann, Bettina Warscheid and Lars Nitschke

J Immunol April 27, 2020, ji1900925; DOI: https://doi.org/10.4049/jimmunol.1900925
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Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155
Jinghua Lu, François Van Laethem, Ingrid Saba, Jonathan Chu, Anastasia N. Tikhonova, Abhisek Bhattacharya, Alfred Singer and Peter D. Sun

J Immunol April 22, 2020, ji1901084; DOI: https://doi.org/10.4049/jimmunol.1901084

NOVEL IMMUNOLOGICAL METHODS

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A Novel Utility to Correct for Plate/Batch/Lot and Nonspecific Binding Artifacts in Luminex Data
Holden T. Maecker, Yael Rosenberg-Hasson, Kathleen Durgin Kolstad, Virginia D. Steen and Lorinda S. Chung

J Immunol May 6, 2020, ji2000017; DOI: https://doi.org/10.4049/jimmunol.2000017
Open Access
Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque through Long Read Transcriptome Sequencing
Author Choice Article

Hayden N. Brochu, Elizabeth Tseng, Elise Smith, Matthew J. Thomas, Aiden M. Jones, Kayleigh R. Diveley, Lynn Law, Scott G. Hansen, Louis J. Picker, Michael Gale Jr. and Xinxia Peng

J Immunol May 6, 2020, ji1901256; DOI: https://doi.org/10.4049/jimmunol.1901256

SYSTEMS IMMUNOLOGY

Open Access
Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination
Author Choice Article

Lucille Adam, Nicolas Tchitchek, Biliana Todorova, Pierre Rosenbaum, Candie Joly, Candice Poux, Catherine Chapon, Anna-Lena Spetz, Mart Ustav, Roger Le Grand and Frédéric Martinon

J Immunol May 8, 2020, ji1900517; DOI: https://doi.org/10.4049/jimmunol.1900517
Open Access
Distinct Features of Human Myeloid Cell Cytokine Response Profiles Identify Neutrophil Activation by Cytokines as a Prognostic Feature during Tuberculosis and Cancer
Author Choice Article

Joseph C. Devlin, Erin E. Zwack, Mei San Tang, Zhi Li, David Fenyo, Victor J. Torres, Kelly V. Ruggles and P’ng Loke

J Immunol April 29, 2020, ji1901133; DOI: https://doi.org/10.4049/jimmunol.1901133

TRANSPLANTATION

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Early T Cell Activation Metrics Predict Graft-versus-Host Disease in a Humanized Mouse Model of Hematopoietic Stem Cell Transplantation
Nicholas J. Hess, Amy W. Hudson, Peiman Hematti and Jenny E. Gumperz

J Immunol May 22, 2020, ji2000054; DOI: https://doi.org/10.4049/jimmunol.2000054

TUMOR IMMUNOLOGY

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Suppression of Mll1-Complex by Stat3/Cebpβ–Induced miR-21a/21b/181b Maintains the Accumulation, Homeostasis, and Immunosuppressive Function of Polymorphonuclear Myeloid-Derived Suppressor Cells
Zhiqian Zhang, Xu Huang, Enlin Wang, Yugang Huang and Rongcun Yang

J Immunol May 1, 2020, ji2000230; DOI: https://doi.org/10.4049/jimmunol.2000230
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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy
Tiffany C. Blair, Shelly Bambina, Alejandro F. Alice, Gwen F. Kramer, Terry R. Medler, Jason R. Baird, Miranda L. Broz, Garth W. Tormoen, Victoria Troesch, Marka R. Crittenden and Michael J. Gough

J Immunol April 27, 2020, ji2000194; DOI: https://doi.org/10.4049/jimmunol.2000194

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ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

BRIEF REVIEWS

CLINICAL AND HUMAN IMMUNOLOGY

CUTTING EDGE

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

SYSTEMS IMMUNOLOGY

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