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AUTOIMMUNITY

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SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation
Author Choice Article

Linjiao Chen, Jing Bai, Danhong Peng, Yuanyuan Gao, Xiaojie Cai, Junxun Zhang, Sibei Tang, Liman Niu, Yang Sun, Fangzhou Lou, Hong Zhou, Qianqian Yin, Zhikai Wang, Libo Sun, Xuemei Du, Zhenyao Xu, Hong Wang, Qun Li and Honglin Wang

J Immunol January 22, 2021, ji2000036; DOI: https://doi.org/10.4049/jimmunol.2000036
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Gut Commensal Segmented Filamentous Bacteria Fine-Tune T Follicular Regulatory Cells to Modify the Severity of Systemic Autoimmune Arthritis
Nicholas A. Bates, Anna Li, Tingting Fan, Madeline P. Cutcliffe, Caitlyn B. Dagenet, Kiah C. Sleiman, Heqing Ma, Shekha Tahsin, Candace S. Garrett, Jesse Altemus and Hsin-Jung Joyce Wu

J Immunol January 18, 2021, ji2000663; DOI: https://doi.org/10.4049/jimmunol.2000663

BRIEF REVIEWS

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Coronavirus Receptors as Immune Modulators
Charan Kumar V. Devarakonda, Emily Meredith, Mallika Ghosh and Linda H. Shapiro

J Immunol December 30, 2020, ji2001062; DOI: https://doi.org/10.4049/jimmunol.2001062

CORRECTIONS

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Correction: Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-κB
Ling Xu, Dandan Yu, Yu-Lin Yao, Tianle Gu, Xiao Zheng, Yong Wu, Rong-Hua Luo, Yong-Tang Zheng, Jin Zhong and Yong-Gang Yao

J Immunol January 13, 2021, ji2001396; DOI: https://doi.org/10.4049/jimmunol.2001396
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Correction: Osa-Containing Brahma Complex Regulates Innate Immunity and the Expression of Metabolic Genes in Drosophila
Susanna Valanne, Mirva Järvelä-Stölting, Sanna-Kaisa E. Harjula, Henna Myllymäki, Tiina S. Salminen and Mika Rämet

J Immunol January 8, 2021, ji2001320; DOI: https://doi.org/10.4049/jimmunol.2001320

CUTTING EDGE

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Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis
Ritesh Kumar, Amir Kumar Singh, Petro Starokadomskyy, Weibo Luo, Arianne L. Theiss, Ezra Burstein and K. Venuprasad

J Immunol January 27, 2021, ji2000015; DOI: https://doi.org/10.4049/jimmunol.2000015
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Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses
Vineet Joag, Sathi Wijeyesinghe, J. Michael Stolley, Clare F. Quarnstrom, Thamotharampillai Dileepan, Andrew G. Soerens, Jules A. Sangala, Stephen D. O’Flanagan, Noah V. Gavil, Sung-Wook Hong, Siddheshvar Bhela, Sailaja Gangadhara, Eyob Weyu, William E. Matchett, Joshua Thiede, Venkatramana Krishna, Maxim C.-J. Cheeran, Tyler D. Bold, Rama Amara, Peter Southern, Geoffrey T. Hart, Luca Schifanella, Vaiva Vezys, Marc K. Jenkins, Ryan A. Langlois and David Masopust

J Immunol January 13, 2021, ji2001400; DOI: https://doi.org/10.4049/jimmunol.2001400

IMMUNE REGULATION

Open Access
Blockade of PD-1/PD-L1 Pathway Enhances the Antigen-Presenting Capacity of Fibrocytes
Author Choice Article

Tania Afroj, Atsushi Mitsuhashi, Hirokazu Ogino, Atsuro Saijo, Kenji Otsuka, Hiroto Yoneda, Makoto Tobiume, Na Thi Nguyen, Hisatsugu Goto, Kazuya Koyama, Masamichi Sugimoto, Osamu Kondoh, Hiroshi Nokihara and Yasuhiko Nishioka

J Immunol January 27, 2021, ji2000909; DOI: https://doi.org/10.4049/jimmunol.2000909
Open Access
The Anti-Inflammatory Immune Response in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease Inhibitor–Mediated Alternative Activation of Macrophages
Author Choice Article

Ning Xu, Xue Bai, Yan Liu, Yaming Yang, Bin Tang, Hai Ning Shi, Isabelle Vallee, Pascal Boireau, Xiaolei Liu and Mingyuan Liu

J Immunol January 25, 2021, ji2000290; DOI: https://doi.org/10.4049/jimmunol.2000290
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Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells
Ting Lu, Li Chen, Anthony G. Mansour, Melissa J. Yu, Noah Brooks, Kun-Yu Teng, Zhenlong Li, Jianying Zhang, Tasha Barr, Jianhua Yu and Michael A. Caligiuri

J Immunol January 8, 2021, ji2000177; DOI: https://doi.org/10.4049/jimmunol.2000177

IMMUNE SYSTEM DEVELOPMENT

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Evidence for Prescribed NK Cell Ly-49 Developmental Pathways in Mice
Alberto J. Millan, Bryan A. Hom, Jeremy B. Libang, Suzanne Sindi and Jennifer O. Manilay

J Immunol January 25, 2021, ji2000613; DOI: https://doi.org/10.4049/jimmunol.2000613

IMMUNOTHERAPY AND VACCINES

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Manganese-Doped Silica-Based Nanoparticles Promote the Efficacy of Antigen-Specific Immunotherapy
Janin Chandra, Siok Min Teoh, Paula Kuo, Lynn Tolley, Abate Assefa Bashaw, Zewen Kelvin Tuong, Yang Liu, Zibin Chen, James W. Wells, Chengzhong Yu, Ian H. Frazer and Meihua Yu

J Immunol January 27, 2021, ji2000355; DOI: https://doi.org/10.4049/jimmunol.2000355
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Interruption of Thymic Activity in Adult Mice Improves Responses to Tumor Immunotherapy
José Almeida-Santos, Marie-Louise Bergman, Inês Amendoeira Cabral and Jocelyne Demengeot

J Immunol January 20, 2021, ji2000626; DOI: https://doi.org/10.4049/jimmunol.2000626
Open Access
Polyfunctional Tier 2–Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor
Author Choice Article

David A. Spencer, Delphine C. Malherbe, Néstor Vázquez Bernat, Monika Ádori, Benjamin Goldberg, Nicholas Dambrauskas, Heidi Henderson, Shilpi Pandey, Tracy Cheever, Philip Barnette, William F. Sutton, Margaret E. Ackerman, James J. Kobie, D. Noah Sather, Gunilla B. Karlsson Hedestam, Nancy L. Haigwood and Ann J. Hessell

J Immunol January 20, 2021, ji2001082; DOI: https://doi.org/10.4049/jimmunol.2001082
Open Access
Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells
Author Choice Article

Gabriela Andrejeva, Benjamin J. Capoccia, Ronald R. Hiebsch, Michael J. Donio, Isra M. Darwech, Robyn J. Puro and Daniel S. Pereira

J Immunol January 11, 2021, ji2001019; DOI: https://doi.org/10.4049/jimmunol.2001019
Open Access
Synergistic Effect of Two Nanotechnologies Enhances the Protective Capacity of the Theileria parva Sporozoite p67C Antigen in Cattle
Author Choice Article

Anna Lacasta, Karishma T. Mody, Ine De Goeyse, Chengzhong Yu, Jun Zhang, James Nyagwange, Stephen Mwalimu, Elias Awino, Rosemary Saya, Thomas Njoroge, Robert Muriuki, Nicholas Ndiwa, Elisabeth Jane Poole, Bing Zhang, Antonino Cavallaro, Timothy J. Mahony, Lucilla Steinaa, Neena Mitter and Vishvanath Nene

J Immunol January 8, 2021, ji2000442; DOI: https://doi.org/10.4049/jimmunol.2000442
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Effective and Safe Stimulation of Humoral and Cell-Mediated Immunity by Intradermal Immunization with a Cyclic Dinucleotide/Nanoparticle Combination Adjuvant
Juan F. Hernandez-Franco, Yung-Yi C. Mosley, Jackeline Franco, Darryl Ragland, Yuan Yao and Harm HogenEsch

J Immunol December 30, 2020, ji2000703; DOI: https://doi.org/10.4049/jimmunol.2000703

INFECTIOUS DISEASE AND HOST RESPONSE

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Semaphorin 3E Protects against Chlamydial Infection by Modulating Dendritic Cell Functions
Rony Thomas, Shuhe Wang, Sudhanshu Shekhar, Ying Peng, Sai Qiao, Chunyan Zhang, Lianyu Shan, Hesam Movassagh, Abdelilah S. Gounni, Jie Yang and Xi Yang

J Immunol January 27, 2021, ji2001013; DOI: https://doi.org/10.4049/jimmunol.2001013
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Mobilization of γδ T Cells and IL-10 Production at the Acute Phase of Hepatitis E Virus Infection in Cytomegalovirus Carriers
Hugo Barragué, Jessica Fontaine, Florence Abravanel, Emilie Mauré, Jean-Marie Péron, Laurent Alric, Martine Dubois, Jacques Izopet and Eric Champagne

J Immunol January 22, 2021, ji2000187; DOI: https://doi.org/10.4049/jimmunol.2000187
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The Phosphoenolpyruvate Carboxykinase Is a Key Metabolic Enzyme and Critical Virulence Factor of Leishmania major
Aida Feiz Barazandeh, Zhirong Mou, Nnamdi Ikeogu, Edgard M. Mejia, Chidalu A. Edechi, Wen-Wei Zhang, Javad Alizadeh, Grant M. Hatch, Saeid Ghavami, Greg Matlashewski, Aaron J. Marshall and Jude E. Uzonna

J Immunol January 18, 2021, ji2000517; DOI: https://doi.org/10.4049/jimmunol.2000517
Open Access
Histidine-Rich Glycoprotein Stimulates Human Neutrophil Phagocytosis and Prolongs Survival through CLEC1A
Author Choice Article

Yohei Takahashi, Hidenori Wake, Masakiyo Sakaguchi, Yukinori Yoshii, Kiyoshi Teshigawara, Dengli Wang and Masahiro Nishibori

J Immunol January 15, 2021, ji2000817; DOI: https://doi.org/10.4049/jimmunol.2000817
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Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Citrobacter rodentium Infection
Yasuka Matsunaga, Trevon Clark, Alanna G. Wanek, Jacob P. Bitoun, Qingqing Gong, Misty Good and Jay K. Kolls

J Immunol January 13, 2021, ji2000591; DOI: https://doi.org/10.4049/jimmunol.2000591
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Acidic Calcium-Independent Phospholipase A2 Regulates Eosinophil-Mediated Pathology during Filarial Manifestation of Tropical Pulmonary Eosinophilia
Pankaj Sharma, Aditi Sharma, Laxmi Ganga, Neha Satoeya, Ruchi Jha and Mrigank Srivastava

J Immunol January 13, 2021, ji2000604; DOI: https://doi.org/10.4049/jimmunol.2000604
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Transcriptional Diversity and Niche-Specific Distribution of Leukocyte Populations during Staphylococcus aureus Craniotomy-Associated Biofilm Infection
Amy L. Aldrich, Christopher M. Horn, Cortney E. Heim, Lee E. Korshoj and Tammy Kielian

J Immunol January 8, 2021, ji2001042; DOI: https://doi.org/10.4049/jimmunol.2001042
Open Access
Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to the Draining Lymph Node
Author Choice Article

Juliana Bernardi Aggio, Veronika Krmeská, Brian J. Ferguson, Pryscilla Fanini Wowk and Antonio Gigliotti Rothfuchs

J Immunol January 8, 2021, ji2000928; DOI: https://doi.org/10.4049/jimmunol.2000928

INNATE IMMUNITY AND INFLAMMATION

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IL-38 Ablation Reduces Local Inflammation and Disease Severity in Experimental Autoimmune Encephalomyelitis
Arnaud Huard, Hoai Nam Do, Ann-Christin Frank, Evelyn Sirait-Fischer, Dominik Fuhrmann, Martine Catharina Josephine Hofmann, Rebecca Raue, Gaby Palmer, Bernhard Brüne, Natasja de Bruin and Andreas Weigert

J Immunol January 27, 2021, ji2000923; DOI: https://doi.org/10.4049/jimmunol.2000923
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Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2
Andrea N. Loes, Melissa N. Hinman, Dylan R. Farnsworth, Adam C. Miller, Karen Guillemin and Michael J. Harms

J Immunol January 20, 2021, ji1901288; DOI: https://doi.org/10.4049/jimmunol.1901288
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Activated Neutrophils Propagate Fetal Membrane Inflammation and Weakening through ERK and Neutrophil Extracellular Trap–Induced TLR-9 Signaling
Mancy Tong, Abigail H. Smith and Vikki M. Abrahams

J Immunol January 20, 2021, ji2001268; DOI: https://doi.org/10.4049/jimmunol.2001268
Open Access
TNF-α Regulates Human Plasmacytoid Dendritic Cells by Suppressing IFN-α Production and Enhancing T Cell Activation
Author Choice Article

Antonios Psarras, Agne Antanaviciute, Adewonuola Alase, Ian Carr, Miriam Wittmann, Paul Emery, George C. Tsokos and Edward M. Vital

J Immunol January 13, 2021, ji1901358; DOI: https://doi.org/10.4049/jimmunol.1901358
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ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages
Naiqi Yang, Yiwei Xiong, Yan Wang, Yulan Yi, Jingfei Zhu, Feng Ma, Jing Li and Hebin Liu

J Immunol January 11, 2021, ji2000569; DOI: https://doi.org/10.4049/jimmunol.2000569
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Hyperglycemic Memory of Innate Immune Cells Promotes In Vitro Proinflammatory Responses of Human Monocytes and Murine Macrophages
Kathrin Thiem, Samuel T. Keating, Mihai G. Netea, Niels P. Riksen, Cees J. Tack, Janna van Diepen and Rinke Stienstra

J Immunol January 11, 2021, ji1901348; DOI: https://doi.org/10.4049/jimmunol.1901348
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Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner
Shanshan Zhang, Mingchao Wang, Chenliang Wang, Guifen Wang, Keyong Sun, Sihan Xiong, Liqing Cheng, Dandan Yang, Xin Lin and Xueqiang Zhao

J Immunol January 8, 2021, ji2001031; DOI: https://doi.org/10.4049/jimmunol.2001031
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Adherence Affects Monocyte Innate Immune Function and Metabolic Reprogramming after Lipopolysaccharide Stimulation In Vitro
Natasja A. Otto, Joe M. Butler, Ivan Ramirez-Moral, Michel van Weeghel, Jeroen W. J. van Heijst, Brendon P. Scicluna, Riekelt H. Houtkooper, Alex F. de Vos and Tom van der Poll

J Immunol January 6, 2021, ji2000702; DOI: https://doi.org/10.4049/jimmunol.2000702
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Inhibition of Efferocytosis by Extracellular CIRP–Induced Neutrophil Extracellular Traps
Kehong Chen, Atsushi Murao, Adnan Arif, Satoshi Takizawa, Hui Jin, Jianxin Jiang, Monowar Aziz and Ping Wang

J Immunol December 30, 2020, ji2000091; DOI: https://doi.org/10.4049/jimmunol.2000091

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Loss of the Transfer RNA Wobble Uridine–Modifying Enzyme Elp3 Delays T Cell Cycle Entry and Impairs T Follicular Helper Cell Responses through Deregulation of Atf4
Pierre Lemaitre, Qiang Bai, Céline Legrand, Alain Chariot, Pierre Close, Fabrice Bureau and Christophe J. Desmet

J Immunol January 22, 2021, ji2000521; DOI: https://doi.org/10.4049/jimmunol.2000521
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Structure and Functional Characterization of a Humanized Anti-CCL20 Antibody following Exposure to Serum Reveals the Formation of Immune Complex That Leads to Toxicity
Andrew S. Thomson, Shing H. Mai, Gerben Bouma, Michael Herdman, Michael Byrne, Charles S. Hottenstein, Joseph Minetti, Stephen Trulli, J. David Taylor, John R. White and Shugui Chen

J Immunol January 22, 2021, ji2000336; DOI: https://doi.org/10.4049/jimmunol.2000336
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The Role of the HLA Class I α2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1
Philippa M. Saunders, Bruce J. MacLachlan, Jacqueline Widjaja, Shu Cheng Wong, Clare V. L. Oates, Jamie Rossjohn, Julian P. Vivian and Andrew G. Brooks

J Immunol January 13, 2021, ji2001109; DOI: https://doi.org/10.4049/jimmunol.2001109
Open Access
Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B
Author Choice Article

Xin Xu, Chi Zhang, Dalton T. Denton, Daniel O’Connell, Daniel W. Drolet and Brian V. Geisbrecht

J Immunol January 8, 2021, ji2001260; DOI: https://doi.org/10.4049/jimmunol.2001260

MUCOSAL IMMUNOLOGY

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Prevailing Role of Mucosal Igs and B Cells in Teleost Skin Immune Responses to Bacterial Infection
Xiao-Ting Zhang, Yong-Yao Yu, Hao-Yue Xu, Zhen-Yu Huang, Xia Liu, Jia-Feng Cao, Kai-Feng Meng, Zheng-Ben Wu, Guang-Kun Han, Meng-Ting Zhan, Li-Guo Ding, Wei-Guang Kong, Nan Li, Fumio Takizawa, J. Oriol Sunyer and Zhen Xu

J Immunol January 25, 2021, ji2001097; DOI: https://doi.org/10.4049/jimmunol.2001097

NOVEL IMMUNOLOGICAL METHODS

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CTLA4-Ig–Based Bifunctional Costimulation Inhibitor Blocks CD28 and ICOS Signaling to Prevent T Cell Priming and Effector Function
Radhika Goenka, Zhenghai Xu, Josue Samayoa, David Banach, Christine Beam, Sahana Bose, Gerri Dooner, Charles M. Forsyth, Xiaoqing Lu, Limary Medina, Ramkrishna Sadhukhan, Bernhard Sielaff, Silvino Sousa, Qingfeng Tao, Debra Touw, Fei Wu, Gillian A. Kingsbury and Yoshiko Akamatsu

J Immunol January 25, 2021, ji2001100; DOI: https://doi.org/10.4049/jimmunol.2001100

SYSTEMS IMMUNOLOGY

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Maternal and Cord Blood 25-Hydroxyvitamin D₃ Are Associated with Increased Cord Blood and Naive and Activated Regulatory T Cells: The Barwon Infant Study
Steffen U. Thorsen, Fiona Collier, Angela Pezic, Martin O’Hely, Michael Clarke, Mimi L. K. Tang, David Burgner, Peter Vuillermin and Anne-Louise Ponsonby

J Immunol January 11, 2021, ji2000515; DOI: https://doi.org/10.4049/jimmunol.2000515
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Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues
Xiaji Liu, Jingyuan Zhang, Angela C. Zeigler, Anders R. Nelson, Merry L. Lindsey and Jeffrey J. Saucerman

J Immunol January 6, 2021, ji1901444; DOI: https://doi.org/10.4049/jimmunol.1901444

TRANSPLANTATION

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MyD88 Costimulation in Donor CD8⁺ T Cells Enhances the Graft-versus-Tumor Effect in Murine Hematopoietic Cell Transplantation
Nicholas G. Ciavattone, Long Wu, Rachel O’Neill, Jingxin Qiu, Eduardo Davila and Xuefang Cao

J Immunol January 6, 2021, ji2000479; DOI: https://doi.org/10.4049/jimmunol.2000479

TUMOR IMMUNOLOGY

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Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression
Zachary P. McKay, Michael C. Brown and Matthias Gromeier

J Immunol January 27, 2021, ji2000792; DOI: https://doi.org/10.4049/jimmunol.2000792
Open Access
Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis
Author Choice Article

Arianna Bianchi, Letizia Marchetti, Zoe Hall, Henrique Lemos, Michele Vacca, Hannah Paish, Kile Green, Bronte Elliott, Dina Tiniakos, João F. Passos, Diana Jurk, Derek A. Mann and Caroline L. Wilson

J Immunol January 13, 2021, ji2001022; DOI: https://doi.org/10.4049/jimmunol.2001022

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AUTOIMMUNITY

BRIEF REVIEWS

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CUTTING EDGE

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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NOVEL IMMUNOLOGICAL METHODS

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