HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients

^*Vaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA;
^†Faculty of Medicine, General Sir John Kotelawala Defense University, Ratmalana, Sri Lanka;
^‡Faculty of Science, University of Colombo, Colombo, Sri Lanka;
^§National Tuberculosis Reference Laboratory, Welisara, Sri Lanka;
^¶National Hospital for Respiratory Diseases, Welisara, Sri Lanka;
^‖South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa;
^#Johns Hopkins School of Public Health, Baltimore, MD;
^**Universidad Peruana Cayetano Heredia, Lima, Peru;
^††Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan;
^‡‡Department of Medicine, City of Hope National Medical Center, Duarte, CA; and
^§§Department of Medicine, University of California San Diego, La Jolla, CA

Address correspondence and reprint requests to Dr. Julie G. Burel and Dr. Bjoern Peters, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA, 92037. E-mail addresses: jburel{at}lji.org (J.G.B.) and bpeters{at}lji.org (B.P.)

The sequences presented in this article have been submitted to the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo) under accession numbers GSE161829 and GSE162725.

R. Tippalagama, M.P., B.P., and J.G.B. conceived and designed the study. A.D.d., S.P., D.V., B.G., N.D.S.G., D.A., T.J.S., R.H.G., M.S., and R. Taplitz provided samples. C.S.L.A., G.S., and P.V. provided technical resources. R. Tippalagama, A. Singhania, P.D., A.C., and J.G.B. conducted the experiments and/or analyzed the data. A. Sette and B.P. provided funding. R. Tippalagama, B.P., and J.G.B. led the data analysis and interpretation with input from all coauthors. R. Tippalagama, B.P., and J.G.B. wrote the manuscript and all authors edited the manuscript.

Funding

Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID)
U19 AI118626