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Cutting Edge: Batf3 Expression by CD8 T Cells Critically Regulates the Development of Memory Populations

Zhijuan Qiu, Camille Khairallah, Galina Romanov and Brian S. Sheridan
J Immunol July 15, 2020, ji2000228; DOI: https://doi.org/10.4049/jimmunol.2000228
Zhijuan Qiu
Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794
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Camille Khairallah
Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794
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Galina Romanov
Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794
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Brian S. Sheridan
Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794
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Key Points

  • Batf3 expression by CD8 T cells critically regulates memory T cell development.

  • Batf3−/− CD8 T cells undergo increased apoptosis during contraction.

  • Batf3−/− CD8 T cells have an impaired recall ability but remain functional.

Abstract

The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell–mediated immunity against intracellular pathogens and tumors. However, whether BATF3 intrinsically regulates CD8 T cell responses is not well studied. In this article, we report a role for cell-intrinsic Batf3 expression in regulating the establishment of circulating and resident memory T cells after foodborne Listeria monocytogenes infection of mice. Consistent with other studies, Batf3 expression by CD8 T cells was dispensable for the primary response. However, Batf3−/− T cells underwent increased apoptosis during contraction to contribute to a substantially reduced memory population. Batf3−/− memory cells had an impaired ability to mount a robust recall response but remained functional. These findings reveal a cell-intrinsic role of Batf3 in regulating CD8 T cell memory development.

Footnotes

  • This work was supported by the National Institute of General Medical Sciences, National Institutes of Health (NIH) Award K12GM102778 (to Z.Q.), National Institute of Allergy and Infectious Diseases, NIH Awards R01AI076457 (to B.S.S.) and R21AI137929 (to B.S.S.), and funds provided by The Research Foundation for the State University of New York and Stony Brook University (to B.S.S.).

  • The online version of this article contains supplemental material.

  • Received March 10, 2020.
  • Accepted June 24, 2020.
  • Copyright © 2020 by The American Association of Immunologists, Inc.

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The Journal of Immunology: 206 (3)
The Journal of Immunology
Vol. 206, Issue 3
1 Feb 2021
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Cutting Edge: Batf3 Expression by CD8 T Cells Critically Regulates the Development of Memory Populations
Zhijuan Qiu, Camille Khairallah, Galina Romanov, Brian S. Sheridan
The Journal of Immunology July 15, 2020, ji2000228; DOI: 10.4049/jimmunol.2000228

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Cutting Edge: Batf3 Expression by CD8 T Cells Critically Regulates the Development of Memory Populations
Zhijuan Qiu, Camille Khairallah, Galina Romanov, Brian S. Sheridan
The Journal of Immunology July 15, 2020, ji2000228; DOI: 10.4049/jimmunol.2000228
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Print ISSN 0022-1767        Online ISSN 1550-6606