Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis

^*Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC 27710;
^†Integrated Laboratory Systems, Inc., and National Institutes of Health, Research Triangle Park, Durham, NC 27709;
^‡Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109;
^§Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC 27709;
^¶Department of Pathology, Duke University Medical Center, Durham, NC 27710;
^‖Department of Medicine, Duke University Medical Center, Durham, NC 27710;
^#Department of Immunology, Duke University Medical Center, Durham, NC 27710; and
^**Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710

Address correspondence and reprint requests to Dr. Xiao-Ping Zhong, Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Room 133 MSRB-I, Research Drive, Box 2644, Durham, NC 27710. E-mail address: xiaoping.zhong{at}duke.edu

P.C., S.W., K.S.J., R.L.Z., W.D., P.K., and S.S. designed and performed experiments and analyzed data, M.S. and L.G.Q. designed experiments and analyzed data. M.B.F., R.L.Z., and P.K. participated in experimental design and manuscript preparation. X.-P.Z. conceived the project, designed experiments, was involved in data analysis, and wrote the manuscript.

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