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Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome

Haipeng Yin, Qiang Guo, Xin Li, Tiantian Tang, Cuiling Li, Hengxiao Wang, Yuanxin Sun, Qi Feng, Chunhong Ma, Chengjiang Gao, Fan Yi and Jun Peng
J Immunol March 16, 2018, ji1701495; DOI: https://doi.org/10.4049/jimmunol.1701495
Haipeng Yin
*Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China;
†Key Laboratory for Tumor Immunology and Traditional Chinese Medicine Immunology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China;
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Qiang Guo
†Key Laboratory for Tumor Immunology and Traditional Chinese Medicine Immunology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China;
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Xin Li
*Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China;
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Tiantian Tang
‡Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China;
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Cuiling Li
†Key Laboratory for Tumor Immunology and Traditional Chinese Medicine Immunology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China;
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Hengxiao Wang
†Key Laboratory for Tumor Immunology and Traditional Chinese Medicine Immunology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China;
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Yuanxin Sun
*Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China;
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Qi Feng
*Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China;
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Chunhong Ma
§Shandong University School of Medicine, Jinan 250012, China; and
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Chengjiang Gao
§Shandong University School of Medicine, Jinan 250012, China; and
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Fan Yi
§Shandong University School of Medicine, Jinan 250012, China; and
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Jun Peng
*Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China;
¶Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan 250012, China
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Abstract

Turmeric is traditionally used as a spice and coloring in foods. Curcumin is the primary active ingredient in the turmeric, and compelling evidence has shown that it has the ability to inhibit inflammation. However, the mechanism mediating its anti-inflammatory effects are not fully understood. We report that curcumin inhibited caspase-1 activation and IL-1β secretion through suppressing LPS priming and the inflammasome activation pathway in mouse bone marrow–derived macrophages. The inhibitory effect of curcumin on inflammasome activation was specific to the NLRP3, not to the NLRC4 or the AIM2 inflammasomes. Curcumin inhibited the NLRP3 inflammasome by preventing K+ efflux and disturbing the downstream events, including the efficient spatial arrangement of mitochondria, ASC oligomerization, and speckle formation. Reactive oxygen species, autophagy, sirtuin-2, or acetylated α-tubulin was ruled out as the mechanism by which curcumin inhibits the inflammasome. Importantly, in vivo data show that curcumin attenuated IL-1β secretion and prevented high-fat diet–induced insulin resistance in wide-type C57BL/6 mice but not in Nlrp3-deficient mice. Curcumin also repressed monosodium urate crystal–induced peritoneal inflammation in vivo. Taken together, we identified curcumin as a common NLRP3 inflammasome activation inhibitor. Our findings reveal a mechanism through which curcumin represses inflammation and suggest the potential clinical use of curcumin in NLRP3-driven diseases.

Footnotes

  • This work was supported by National Natural Science Foundation of China Grants 81370623, 81401314, 91442204, 81125002, and 81321061, Natural Sciences Foundation of Shandong Province Grant ZR2010HQ005, the Innovation Project of the Shandong Academy of Medical Sciences, and by the Project for Laureate of Taishan Scholar (Grant ts201511075).

  • The online version of this article contains supplemental material.

  • Received October 27, 2017.
  • Accepted February 21, 2018.
  • Copyright © 2018 by The American Association of Immunologists, Inc.
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The Journal of Immunology: 209 (1)
The Journal of Immunology
Vol. 209, Issue 1
1 Jul 2022
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Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome
Haipeng Yin, Qiang Guo, Xin Li, Tiantian Tang, Cuiling Li, Hengxiao Wang, Yuanxin Sun, Qi Feng, Chunhong Ma, Chengjiang Gao, Fan Yi, Jun Peng
The Journal of Immunology March 16, 2018, ji1701495; DOI: 10.4049/jimmunol.1701495

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Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome
Haipeng Yin, Qiang Guo, Xin Li, Tiantian Tang, Cuiling Li, Hengxiao Wang, Yuanxin Sun, Qi Feng, Chunhong Ma, Chengjiang Gao, Fan Yi, Jun Peng
The Journal of Immunology March 16, 2018, ji1701495; DOI: 10.4049/jimmunol.1701495
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