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Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis

Sofia Björnfot Holmström, Reuben Clark, Stephanie Zwicker, Daniela Bureik, Egle Kvedaraite, Eric Bernasconi, Anh Thu Nguyen Hoang, Gunnar Johannsen, Benjamin J. Marsland, Elisabeth A. Boström and Mattias Svensson
J Immunol November 3, 2017, ji1700672; DOI: https://doi.org/10.4049/jimmunol.1700672
Sofia Björnfot Holmström
*Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden;
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Reuben Clark
†Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden;
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Stephanie Zwicker
†Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden;
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Daniela Bureik
†Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden;
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Egle Kvedaraite
*Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden;
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Eric Bernasconi
‡Service of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1066 Epalinges, Switzerland; and
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Anh Thu Nguyen Hoang
*Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden;
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Gunnar Johannsen
§Danakliniken Specialist Dental Care, 182 31 Danderyd, Sweden
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Benjamin J. Marsland
‡Service of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1066 Epalinges, Switzerland; and
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Elisabeth A. Boström
†Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden;
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Mattias Svensson
*Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden;
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Article Information

ji1700672
DOI 
https://doi.org/10.4049/jimmunol.1700672
PubMed 
29101312

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received May 8, 2017
  • Accepted October 6, 2017
  • Published online November 3, 2017.

Article Versions

  • You are currently viewing an Older version of this article (November 3, 2017 - 05:14).
  • Newer version (November 8, 2017 - 07:08).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2017 by The American Association of Immunologists, Inc.

Author Information

  1. Sofia Björnfot Holmström*,
  2. Reuben Clark†,
  3. Stephanie Zwicker†,
  4. Daniela Bureik†,
  5. Egle Kvedaraite*,
  6. Eric Bernasconi‡,
  7. Anh Thu Nguyen Hoang*,
  8. Gunnar Johannsen§,
  9. Benjamin J. Marsland‡,
  10. Elisabeth A. Boström† and
  11. Mattias Svensson*
  1. *Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden;
  2. †Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden;
  3. ‡Service of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1066 Epalinges, Switzerland; and
  4. §Danakliniken Specialist Dental Care, 182 31 Danderyd, Sweden
  1. Address correspondence and reprint requests to Dr. Mattias Svensson, Center for Infectious Medicine, F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden. E-mail address: mattias.svensson{at}ki.se
  1. S.B.H. and E.A.B. contributed to the study design, performed the experiments, analyzed the data, interpreted the results, and prepared the figures; G.J. cared for patients and provided tissue samples and clinical data; R.C., S.Z., D.B., E.K., and E.B. performed experiments and interpretation of the results; A.T.N.H. contributed together with S.B.H. establishing the three-dimensional gingival tissue model; B.J.M. contributed to the study design and to interpretation of the results; S.B.H. and M.S. initiated the study; M.S. supervised the study, contributed to the study design and analysis and interpretation of the results, and prepared the figures; S.B.H., E.A.B., and M.S. wrote the manuscript; and all of the authors participated in editing and finalizing the manuscript, which was approved by all authors.

Article usage

Article usage: November 2017 to July 2022

AbstractFullPdf
Nov 201711754106
Dec 20174929942
Total 20171667103148
Jan 20181354328
Feb 201868119
Mar 2018762111
Apr 2018511815
May 2018811110
Jun 201872208
Jul 201848135
Aug 201842106
Sep 201835165
Oct 201874247
Nov 2018602534
Dec 2018122719
Total 2018754239157
Jan 2019174627
Feb 2019162830
Mar 2019174936
Apr 2019253826
May 2019206521
Jun 2019173226
Jul 2019185737
Aug 20192234151
Sep 20192334169
Oct 20192445132
Nov 2019264959
Dec 2019236737
Total 2019248544751
Jan 2020305644
Feb 2020274144
Mar 2020377154
Apr 2020183723
May 202085040
Jun 202015617
Jul 202043426
Aug 202064030
Sep 202013415
Oct 202043629
Nov 2020103629
Dec 2020113114
Total 2020157522365
Jan 202152114
Feb 202182624
Mar 202152425
Apr 202141820
May 202133012
Jun 202141619
Jul 20214179
Aug 202111825
Sep 202152838
Oct 202151936
Nov 2021124342
Dec 2021133533
Total 202169295297
Jan 202243724
Feb 202252424
Mar 2022102932
Apr 202281821
May 2022272639
Jun 202211922
Jul 202251414
Total 202260167176
Total295518701894

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The Journal of Immunology: 209 (4)
The Journal of Immunology
Vol. 209, Issue 4
15 Aug 2022
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Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis
Sofia Björnfot Holmström, Reuben Clark, Stephanie Zwicker, Daniela Bureik, Egle Kvedaraite, Eric Bernasconi, Anh Thu Nguyen Hoang, Gunnar Johannsen, Benjamin J. Marsland, Elisabeth A. Boström, Mattias Svensson
The Journal of Immunology November 3, 2017, ji1700672; DOI: 10.4049/jimmunol.1700672

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Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis
Sofia Björnfot Holmström, Reuben Clark, Stephanie Zwicker, Daniela Bureik, Egle Kvedaraite, Eric Bernasconi, Anh Thu Nguyen Hoang, Gunnar Johannsen, Benjamin J. Marsland, Elisabeth A. Boström, Mattias Svensson
The Journal of Immunology November 3, 2017, ji1700672; DOI: 10.4049/jimmunol.1700672
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Print ISSN 0022-1767        Online ISSN 1550-6606