Summary
The reaction of specific antigens with leucocytes from sensitive donors has been studied. Under appropriate conditions antigen will combine with the cells at 37°C or at 4°C and in the presence or absence of Ca++ and Mg++ without the release of significant quantities of intracellular histamine. Washed primed cells will release their histamine upon incubation at 37°C in buffer containing Ca++ and Mg++ but in the absence of added antigen.
Footnotes
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↵2 Career Development Investigator Awardee, Public Health Service Research Grant No. 5-K3-19, 460-02.
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↵1 This investigation was supported in part by Public Health Service Research Grant A106139-03 from the National Institute of Allergy and Infectious Diseases and the Ernest S. Bazley Asthmatic Research Fund, Chicago Wesley Memorial Hospital.
- Received July 19, 1966.
- Copyright © 1966 by The American Association of Immunologists, Inc.
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