Summary
Guinea pig antigen, sheep red cells (type R), human group A1 red cells and soluble specific blood group substance A contain a similar A-like antigenic determinant. The A-like antigen of certain pig red cells (API) reacts with “immune” but not with “naturally occurring” anti-A antibody in human serum. Pig Ap red cells also absorb anti-sheep red cell hemolysin from human sera containing “immune” anti-A antibody, but not from those containing “naturally occurring” anti-A; furthermore, such cells do not absorb the anti-sheep red cell hemolysin present in immune rabbit serum. These results suggest that immune group O sera may contain an antibody specific against both A antigen and Forssman antigen.
Footnotes
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↵1 Supported by Grants AM-8527 and H-5997 from the United States Public Health Service and by Contract Nonr-3656(12) (NR 105-308) between the Office of Naval Research, Department of the Navy, and the Department of Medicine, University of California School of Medicine, San Francisco, California.
Genetic paper no. 7-112, Pacific Biomedical Research Center Contribution.
- Received September 13, 1965.
- Copyright © 1966 by The American Association of Immunologists, Inc.
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