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The Effect of the Scorbutic State on Tuberculin Hypersensitivity in the Guinea Pig

I. Passive Transfer of Tuberculin Hypersensitivity

Burton Zweiman, William F. Schoenwetter and Eugene A. Hildreth
J Immunol February 1, 1966, 96 (2) 296-300;
Burton Zweiman
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William F. Schoenwetter
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Eugene A. Hildreth
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Summary

  1. 1. An attempt to characterize the previously noted depression of tuberculin skin reactivity in the scorbutic guinea pig was made, utilizing cell transfer techniques.

  2. 2. Scorbutic guinea pigs manifested markedly reduced tuberculin skin responses after receiving complete Freund's adjuvant. This was accompanied by an almost completely absent mononuclear inflammatory response. The inflammatory response to 1% benzyl alcohol, an irritant, was likewise reduced in these animals. In the majority of experiments, pooled cells from these scorbutic animals were able to transfer tuberculin hypersensitivity to normal recipients.

  3. 3. By contrast, equal numbers of cells from tuberculin-sensitive donors did not transfer tuberculin hypersensitivity to scorbutic recipients.

Footnotes

  • ↵1 United States Public Health Service Post-Doctoral Fellow 1-F2-A1-20,484-01.

    Present address: St. Louis Park Clinic, Minneapolis, Minnesota.

  • Received August 24, 1965.
  • Copyright © 1966 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 96, Issue 2
1 Feb 1966
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The Effect of the Scorbutic State on Tuberculin Hypersensitivity in the Guinea Pig
Burton Zweiman, William F. Schoenwetter, Eugene A. Hildreth
The Journal of Immunology February 1, 1966, 96 (2) 296-300;

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The Effect of the Scorbutic State on Tuberculin Hypersensitivity in the Guinea Pig
Burton Zweiman, William F. Schoenwetter, Eugene A. Hildreth
The Journal of Immunology February 1, 1966, 96 (2) 296-300;
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Print ISSN 0022-1767        Online ISSN 1550-6606