Summary
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1. An attempt to characterize the previously noted depression of tuberculin skin reactivity in the scorbutic guinea pig was made, utilizing cell transfer techniques.
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2. Scorbutic guinea pigs manifested markedly reduced tuberculin skin responses after receiving complete Freund's adjuvant. This was accompanied by an almost completely absent mononuclear inflammatory response. The inflammatory response to 1% benzyl alcohol, an irritant, was likewise reduced in these animals. In the majority of experiments, pooled cells from these scorbutic animals were able to transfer tuberculin hypersensitivity to normal recipients.
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3. By contrast, equal numbers of cells from tuberculin-sensitive donors did not transfer tuberculin hypersensitivity to scorbutic recipients.
Footnotes
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↵1 United States Public Health Service Post-Doctoral Fellow 1-F2-A1-20,484-01.
Present address: St. Louis Park Clinic, Minneapolis, Minnesota.
- Received August 24, 1965.
- Copyright © 1966 by The American Association of Immunologists, Inc.
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