Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

Studies on Heterologous Anti-Lymphocyte Serum in Mice

I. In vitro and In vivo Properties

J. G. Gray, Anthony P. Monaco, Mary L. Wood and Paul S. Russell
J Immunol February 1, 1966, 96 (2) 217-228;
J. G. Gray
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anthony P. Monaco
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mary L. Wood
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul S. Russell
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

  1. 1. Rabbits were immunized with suspensions of lymph node cells from A/Jax mice.

  2. 2. The resulting antiserum (RAMLS) contained antibodies to A/Jax lymph node cells, demonstrable as cytotoxins and agglutinins, and antibodies to other mouse tissues and mouse serum proteins demonstrable as precipitins.

  3. 3. The RAMLS caused a specific lymphopenia when given to mice.

  4. 4. Absorption of antibodies to nonlymphatic mouse tissues and to mouse serum proteins did not alter the cytotoxic or agglutinating effect of the RAMLS on lymphocytes and did not alter the in vivo lymphopenic effect.

  5. 5. Chronic administration of RAMLS resulted in sustained lymphopenia during the period of serum treatment without significant morbidity or mortality.

  6. 6. Mice chronically treated with RAMLS do not make antibody to rabbit γ-globulin as readily as those given normal rabbit serum.

  7. 7. Histologic studies of mice chronically treated with RAMLS show depletion and destruction of tissue lymphocytes in lymphoid organs. A similar state of profound lymphocyte depletion can be achieved by a short, intensive course of RAMLS treatment.

Footnotes

  • ↵1 This work was supported in part by Grants AM 07055, AI 06320, T4 CA 5018 and CRTY 5018 from the United States Public Health Service and by the William F. Milton Fund of the Harvard University.

    This is publication No. 1237 of the Cancer Commission of Harvard University.

  • Received July 22, 1965.
  • Copyright © 1966 by The American Association of Immunologists, Inc.

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Log in using your username and password

Forgot your user name or password?
PreviousNext
Back to top

In this issue

The Journal of Immunology
Vol. 96, Issue 2
1 Feb 1966
  • Table of Contents
  • Table of Contents (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Studies on Heterologous Anti-Lymphocyte Serum in Mice
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Studies on Heterologous Anti-Lymphocyte Serum in Mice
J. G. Gray, Anthony P. Monaco, Mary L. Wood, Paul S. Russell
The Journal of Immunology February 1, 1966, 96 (2) 217-228;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Studies on Heterologous Anti-Lymphocyte Serum in Mice
J. G. Gray, Anthony P. Monaco, Mary L. Wood, Paul S. Russell
The Journal of Immunology February 1, 1966, 96 (2) 217-228;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

Cited By...

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • Public Access
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2021 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606