Summary
When guinea pigs were immunized with herpes simplex virus, complement-requiring neutralizing (CRN) antibody, which was specific, appeared 1 week later and reached a considerable level before rises of CF and noncomplement-requiring neutralizing antibodies. Examination of patient sera proved that a similar immune response occurred as a result of herpes virus infections. Normal healthy persons showed no neutralizing antibody which could be enhanced by complement to such a marked extent. Hence, the detection of CRN antibody in a single serum sample became a new method for early diagnosis of herpetic infections. Among 53 patients, whose diagnosis was not possible with usual methods, two were diagnosed as being strongly suspected of herpetic infections by the demonstration of anti-herpes CRN antibody.
- Received July 12, 1965.
- Copyright © 1966 by The American Association of Immunologists, Inc.
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
Log in using your username and password
In this issue
