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Pathogenesis of Venezuelan Equine Encephalomyelitis Virus

II. Infection in Young Adult Mice

William D. Kundin
J Immunol January 1, 1966, 96 (1) 49-58;
William D. Kundin
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Summary

The pathogenesis of an attenuated and an unattenuated strain of Venezuelan equine encephalomyelitis (VEE) virus was studied in young adult mice by means of infectivity titrations and fluorescent antibody staining. Tissue infectivity and viral lethality were generally similar in mice inoculated intracerebrally (i.c.) or subcutaneously (s.c.) with unattenuated virus and i.c. with attenuated virus. The tissues most involved were brain, salivary glands, inguinal nodes and spleen. Mice inoculated s.c. with attenuated VEE virus survived the infection. Little virus was found in the brain.

Footnotes

  • ↵1 Supported by a grant from the United States Army Biological Laboratories, Ft. Detrick, Maryland.

    In conducting the research project herein, the investigators adhered to “Principles of Laboratory Animal Care” as established by the National Society for Medical Research.

  • Received June 18, 1965.
  • Copyright © 1966 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 96, Issue 1
1 Jan 1966
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Pathogenesis of Venezuelan Equine Encephalomyelitis Virus
William D. Kundin
The Journal of Immunology January 1, 1966, 96 (1) 49-58;

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Pathogenesis of Venezuelan Equine Encephalomyelitis Virus
William D. Kundin
The Journal of Immunology January 1, 1966, 96 (1) 49-58;
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Print ISSN 0022-1767        Online ISSN 1550-6606