Summary
Corticosteroid administration in experimental staphylococcal bacteremia in dogs:
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1. Helped to maintain a bacteremic state.
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2. Caused a most severe clinical illness, debilitation and weight loss, sometimes terminating in death.
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3. Caused the most prominent drop in hematocrit and rise in white blood cell count.
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4. Altered serum complement levels by causing them to decrease and/or prevented the occurrence of an expected increase seen in dogs receiving no corticosteroids.
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5. Had no influence on the development of Staphylococcus aureus agglutinins.
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6. Caused a less prominent total protein increase and a more rapid return to normal than those observed in dogs receiving no corticosteroids.
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7. Caused a prominent drop of serum albumin and increase in α3-globulin with these changes returning back to normal more rapidly than in experimental animals receiving no corticosteroids.
Footnotes
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↵1 Supported by United States Public Health Service C-5440, Graduate Research Fund, and Crego Research Fund of the University of Illinois, Chicago, Illinois.
- Received May 17, 1965.
- Copyright © 1966 by The American Association of Immunologists, Inc.
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