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Mechanisms of γ-Globulin Synthesis

Saroj Tawde, Matthew D. Scharff and Jonathan W. Uhr
J Immunol January 1, 1966, 96 (1) 1-7;
Saroj Tawde
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Matthew D. Scharff
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Jonathan W. Uhr
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Summary

Protein synthesis has been studied in lymph node cells obtained from rabbits hyperimmunized to bacteriophage T2. Provided ribonuclease activity was inhibited, almost all nascent protein synthesis occurred on polyribosomes. Pretreatment with 1 µg/ml actinomycin D, 7 hr prior to labeling, caused an 80% reduction of polyribosome-directed protein synthesis. Pulse-labeling studies of similar cell populations indicated that depression of RNA synthesis preceded the reduction of protein and γ-globulin synthesis. When actinomycin D-treated cells were infected with Newcastle disease virus (an RNA virus), cells which had already ceased to make RNA and protein started to synthesize these macromolecules at rapid rates. Thus, the final steps of γ-globulin synthesis by immune lymph node cells appear similar to those of protein synthesis in HeLa cells.

Footnotes

  • ↵2 Recipient of a United States Public Health Service Career Development Award.

  • ↵1 This investigation was supported by United States Public Health Service Research Grant No. AI-01821-08 and by the National Science Foundation Grant No. B-13118. It was done under the sponsorship of the Commission on Immunization of the Armed Forces Epidemiological Board and supported in part by the Office of The Surgeon General, Department of the Army.

  • Received June 14, 1965.
  • Copyright © 1966 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 96, Issue 1
1 Jan 1966
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Mechanisms of γ-Globulin Synthesis
Saroj Tawde, Matthew D. Scharff, Jonathan W. Uhr
The Journal of Immunology January 1, 1966, 96 (1) 1-7;

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Mechanisms of γ-Globulin Synthesis
Saroj Tawde, Matthew D. Scharff, Jonathan W. Uhr
The Journal of Immunology January 1, 1966, 96 (1) 1-7;
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Print ISSN 0022-1767        Online ISSN 1550-6606