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Studies on the Catabolism of γG Subunits and Chains

H. L. Spiegelberg and W. O. Weigle
J Immunol December 1, 1965, 95 (6) 1034-1040;
H. L. Spiegelberg
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W. O. Weigle
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Summary

The catabolism of I131 labeled H- and L-chain of RGG and HGG, Bence Jones protein and H-chain protein was studied in rabbits. Evidence is presented that the molecular structure responsible for the persistence in the circulation of γG is localized in the H-chain.

  1. 1. The H-chain was slowly eliminated from the circulation similar to reduced and alkylated γG.

  2. 2. The H-chain protein, obtained from patients with H-chain disease, was eliminated from the circulation with a half-life not significantly different from that of HGG. Two populations of H-chain protein with different electrophoretic mobilities were separated by DEAE-cellulose chromatography. Both populations were catabolized at the same rate. The rabbits did not excrete the H-chain protein in the urine.

  3. 3. The L-chain and the Bence Jones protein were very rapidly eliminated from the circulation. A significant amount of the L-chain obtained from RGG but not from HGG was excreted in the urine as protein bound radioactivity.

Sialic acid was shown not to be an important part of the structure necessary for the persistence in the circulation of γG. Removal of sialic acid did not change the rate of elimination of HGG, HGG papain Fc fragment and an H-chain protein preparation with a low sialic acid content. In contrast, a large portion of the H-chain protein preparations with a high sialic acid content was rapidly eliminated and catabolized after removal of sialic acid.

Footnotes

  • ↵3 Supported by United States Public Health Research Career Award (5-K6-GM-6936).

  • ↵1 This is Publication No. 117 from the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. This work was supported by United States Public Health Service Grant AI-03882 and AEC contract AT (04-3)-410.

  • Received May 24, 1965.
  • Copyright © 1965 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 95, Issue 6
1 Dec 1965
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Studies on the Catabolism of γG Subunits and Chains
H. L. Spiegelberg, W. O. Weigle
The Journal of Immunology December 1, 1965, 95 (6) 1034-1040;

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Studies on the Catabolism of γG Subunits and Chains
H. L. Spiegelberg, W. O. Weigle
The Journal of Immunology December 1, 1965, 95 (6) 1034-1040;
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Print ISSN 0022-1767        Online ISSN 1550-6606