Summary
The binding of homologous hapten by antibody to the positively charged p-azophenyltrimethylammonium ion was found to be decreased by inorganic cations but not by anions. This appears due to the competition of the cations with the hapten for the negative charge in the specific site of the antibody molecule.
The order of effect for singly charged cations is Cs+ > Rb+ > NH+4 ≥ K+ > Na+ ≥ Li+, which is in the order of the ionic radii and the inverse order of the radius of the hydrated ions. For doubly charged cations the order is Ba++ > Ca++ > Mg++.
Footnotes
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↵This research was supported in part by Grant E-2342 from the National Institute of Allergy and Infectious Disease, National Institutes of Health, United States Public Health Service.
- Received August 3, 1961.
- Copyright © 1962 by The American Association of Immunologists, Inc.
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