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Antibody Response of Adult Chickens to Infectious and Noninfectious Foot-and-Mouth Disease Virus

O. N. Fellowes
J Immunol April 1, 1962, 88 (4) 488-493;
O. N. Fellowes
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Summary

Lesions suggestive of infection were observed in or on the mouth, combs and feet of chickens inoculated with Type A-119 virus propagated in tissue culture. Lesions were not observed in chickens inoculated with Type A-GB virus propagated in guinea pig footpads.

A high titer of neutralizing antibody was induced in adult chickens by inoculation of 1 and 2 ml of either infectious or noninfectious Type A-119 virus grown in tissue culture. Infectious Type A-GB, propagated in guinea pig pads, produced a relatively low titer of neutralizing antibody in chickens.

Both strains, 119 and GB, of infectious Type A virus produced a good response of complement-fixing antibody in chickens as tested by a modified direct complement fixation test.

No evidence of infection was found in normal chickens held with infected birds in the same cage.

  • Received June 26, 1961.
  • Copyright, 1962, by The Williams & Wilkins Company
  • Copyright © 1962 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 88, Issue 4
1 Apr 1962
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Antibody Response of Adult Chickens to Infectious and Noninfectious Foot-and-Mouth Disease Virus
O. N. Fellowes
The Journal of Immunology April 1, 1962, 88 (4) 488-493;

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Antibody Response of Adult Chickens to Infectious and Noninfectious Foot-and-Mouth Disease Virus
O. N. Fellowes
The Journal of Immunology April 1, 1962, 88 (4) 488-493;
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Print ISSN 0022-1767        Online ISSN 1550-6606