Summary
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1. Of 20 rabbits immunized with adult human hemoglobin, 10 eventually gave good precipitating antisera, 5 gave weak antisera and 5 had not produced precipitins after three courses of injections.
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2. When mixed with hemoglobin all the antisera gave red precipitates and were able to precipitate completely adult and cord blood hemoglobin in optimal proportions or antiserum excess.
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3. The antisera did not agglutinate human red cells.
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4. Three of six antisera tested were able to annul the action of carbonic anhydrase.
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5. Absorption experiments with two antisera showed a serological distinction between the major hemoglobin components of a cord blood and an adult blood.
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6. Reactions of the antisera suggest the presence of two or more antigenically distinct hemoglobins in a single sample of blood from one adult.
- Received June 14, 1961.
- Copyright, 1962, by The Williams & Wilkins Company
- Copyright © 1962 by The American Association of Immunologists, Inc.
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