Summary
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1. Removal of the bursa of Fabricius at 1 day of age effectively prevents a large percentage of the animals from producing precipitins to bovine serum albumin (BSA) when inoculations are made to 20 weeks of age. Bursectomy at 10 days is less effective.
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2. Two steroid hormones, 19-nortestosterone and 17-ethyl-19-nortestosterone, administered on the 12th or 13th day of incubation, cause a 5- to 20-fold reduction in bursal weight. Correspondingly, precipitin production against BSA is grossly impaired. Spleen, thymus and body weights were not consistently affected.
Footnotes
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↵1 These studies were aided by Grants A-804(C11) USPHS administered by Professor R. K. Meyer and NSF Grant No. G 13131 administered by Professor H. R. Wolfe.
- Received June 6, 1961.
- Copyright, 1962, by The Williams & Wilkins Company
- Copyright © 1962 by The American Association of Immunologists, Inc.
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