Summary
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1. Using agar overlaid primate cell cultures, a plaque-forming agent was obtained from human whole blood whereas cytopathic effects were not evident in parallel fluid cultures.
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2. This agent, termed the DA virus, was classified as a myxovirus and was found to have biologic properties similar to those of the mumps-NDV group.
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3. Using techniques of neutralization of infectivity either by plaque reduction or by hemadsorption-inhibition the DA virus was found to be antigenically distinct from influenza A, B and C, Newcastle disease, and parainfluenza 1, 2, 3 and 4 viruses. Some degree of antigenic similarity was found to mumps virus. A complete serologic cross-reaction was found between the DA virus and the SA and SV-5 viruses.
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4. Normal monkeys were found to have antibodies to the DA virus while in captivity.
Footnotes
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↵1 Aided by a grant from the National Foundation and conducted under the auspices of the Commission on Viral Infections of the Armed Forces Epidemiology Board and Supported in part by the Office of the Surgeon General, Department of the Army.
- Received May 26, 1961.
- Copyright, 1962, by The Williams & Wilkins Company
- Copyright © 1962 by The American Association of Immunologists, Inc.
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