Summary
Hyperimmune antipoliovirus rabbit γ-globulin has been prepared which contains up to 200-fold more neutralizing antibody/unit volume than human Red Cross γ-globulin. When given to man these antibodies could not be detected in the cerebrospinal fluid in one patient.
Used in therapy of type 1 (Mahoney) poliomyelitis in rhesus monkeys, the rabbit γ-globulin protected a small percentage of the monkeys and was superior to human γ-globulin. It was most effective when given at the time of intramuscular challenge of the monkeys, probably less effective after an interval of 24 or 48 hr and not effective if given after paralysis was apparent.
- Received September 25, 1957.
- Copyright © 1958 by The American Association of Immunologists, Inc.
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
Log in using your username and password
In this issue
