Studies in Endothelial Permeability. III

Abstract

In the preceding paper we have pointed out that in anaphylactic shock in the dog the lymph proteins show considerable modification, depending to a large extent on the dose used for reinjection. From previous studies that we have made with the enzyme mobilization during anaphylactic shock and from the work of Dale (1), Manwaring (2) and others, it seems most probable to us that the lymph proteins are modified by several factors. First, the alteration in the permeability of the endothelium which permits a large amount of blood plasma suddenly to flood into the lymph spaces of the mesenteric area, especially with the increased intraportal pressure which is at once evident in anaphylactic shock. Second, the proteins derived from the liver and other abdominal viscera under shock conditions; these would include particularly the larger molecular aggregates, fibrinogen, globulins, etc.