Summary
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1. The portal blood pressure increases about 7 mm. Hg during the first forty-five seconds of peptone shock. The pressure then gradually falls, reaching normal in from eight to twelve minutes.
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2. Perfusions of isolated livers show an increased resistance to perfusion flow as a result of the action of peptone or of peptone-blood mixtures. The resistance reaches a maximum during the second minute, and then gradually decreases, being restored to approximately normal by the tenth minute.
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3. Mechanically increased resistance to hepatic outflow sufficient to raise the portal blood pressure 10 mm. Hg, the maximum rise during peptone shock, does not cause the hepatic-intestinal cyanosis characteristic of the peptone reaction, nor the characteristic fall in carotid blood pressure.
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4. Theories of peptone shock based solely on the hepatic mechanical factor are, therefore, no longer tenable.
- Received August 27, 1922.
- Copyright © 1923 by The American Association of Immunologists, Inc.
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