Summary
The time of onset of cutaneous hypersensitivity in chickens infected with ornithosis virus was related to the LD50 used for infection. Hypersensitivity developed within 4 weeks of infection and was detected for 1 year after infection. Complement-fixation inhibition antibody appeared earlier in the infection than detectable allergy, although after 7 weeks of infection the serological and skin-test methods agreed in approximately 80% of the infected chickens. The skin-test antigen was resistant to periodate, trypsin, desoxyribonuclease, and exposure to 90°C. The complement-fixing and allergenic activities were separated by ultracentrifugal sedimentation of the complement-fixing antigen. The skin-test antigen was standardized on a nitrogen basis in guinea pigs and chickens.
Footnotes
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↵1 This study was supported in part by funds provided under Contract AF 18(600)-464 with the USAF School of Aviation Medicine, Randolph Field, Texas, and in part by the Texas Turkey Federation.
- Received March 5, 1956.
- Copyright © 1956 by The American Association of Immunologists, Inc.
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