Summary
Although it has been demonstrated that PVP of very high molecular weight (K-87) is antigenic in man, these findings have little bearing with regard to the consideration of PVP K-30 as a suitable plasma expander. PVP was not antigenic in the rabbit under all of the conditions of immunization used. Evidence has been presented that the material precipitated by PVP was specific antibody. The estimation of the level of antibody in different individuals at various times indicated a persistence in some volunteers and a disappearance in others.
Footnotes
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↵1 This investigation was supported by a grant from the Office of the Surgeon General, Department of the Army, Contract No. DA 49-007-MD-248.
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↵2 Presented in part before the 3rd International Biochemical Congress (Brussels, Belgium), September 1955 and at the Fortieth Annual meeting of the American Association of Immunologists, Atlantic City, New Jersey, April 1956.
- Received February 27, 1956.
- Copyright © 1956 by The American Association of Immunologists, Inc.
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