Summary
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1. Purified human blood group A substance from ovarian cysts may be rendered fully antigenic in rabbits by immunising with a streptococcal vaccine in which the organisms are “coated” with the substance.
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2. Specific precipitating antibody is obtained both in rabbits whose tissues contain A-like substance, and in rabbits which lack this substance.
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3. Evidence is presented that the antibodies produced by the two types of rabbit differ sharply in both specificity and serologic characteristics.
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4. Antibody obtained by this method in rabbits whose tissues contain A-like substance cannot be obtained by immunizing with human group-A red cells.
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5. The relationship of these findings to the problem of auto-antibody production is discussed.
Footnotes
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↵1 Aided by a grant from the Medical Research Council.
- Received October 4, 1955.
- Copyright © 1956 by The American Association of Immunologists, Inc.
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