Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

Antibody Formation and the Effect of X-Radiation on Circulating Antibody Levels in the Hypophysectomized Rat

C. Susan Nagareda
J Immunol August 1, 1954, 73 (2) 88-94;
C. Susan Nagareda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Summary

  1. 1. Qualitative data on the effect of hypophysectomy and X-irradiation on anti-sheep erythrocyte hemolysin titers of rat sera have been presented.

  2. 2. Hypophysectomy did not alter the antisheep erythrocyte hemolysin titers of rat sera when animals were injected with antigen 12, 24 and 72 hours, or 6, 15, 24, 42 or 60 days after hypophysectomy.

  3. 3. Hypophysectomized rats exposed to a single dose of total body X-radiation of 500 r (41 or 59 days after hypophysectomy) showed a marked inhibition of antibody formation when injected with an intravenous injection of a 0.25% suspension of washed sheep erythrocytes 24 hours after X-ray exposure while animals exposed to the same radiation dose with the spleens shielded by lead were capable of producing antibodies as indicated by the rise in hemolysin titers.

  4. 4. The role of the pituitary-adrenal system on antibody formation and release is discussed.

  5. 5. It is concluded that in the rat the pituitary is not necessary for the production of anti-sheep hemolysins observed under the conditions of the experiments reported here.

Footnotes

  • ↵2 The author wishes to thank Dr. Leon O. Jacobson for his kind support and encouragement in the pursuit of this investigation. She is also indebted to Dr. Robert W. Wissler for many helpful suggestions during the conduct of this work, and to Mrs. Melba J. Robson for technical advice and assistance.

  • ↵1 This work was done during the tenure of an Atomic Energy Commission Post-doctoral Research Fellowship in Biological Sciences of the National Research Council.

  • Received January 17, 1954.
  • Copyright © 1954 by The American Association of Immunologists, Inc.

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Log in using your username and password

Forgot your user name or password?
PreviousNext
Back to top

In this issue

The Journal of Immunology
Vol. 73, Issue 2
1 Aug 1954
  • Table of Contents
  • Table of Contents (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Antibody Formation and the Effect of X-Radiation on Circulating Antibody Levels in the Hypophysectomized Rat
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Antibody Formation and the Effect of X-Radiation on Circulating Antibody Levels in the Hypophysectomized Rat
C. Susan Nagareda
The Journal of Immunology August 1, 1954, 73 (2) 88-94;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Antibody Formation and the Effect of X-Radiation on Circulating Antibody Levels in the Hypophysectomized Rat
C. Susan Nagareda
The Journal of Immunology August 1, 1954, 73 (2) 88-94;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

Cited By...

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • Public Access
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2021 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606