Summary
The temporal development of complement fixing antibodies against Conn-5 and Easton-2 Coxsackie (C) viruses in the mouse has been studied. These antibodies reach their peak about one month after vaccination and then fall more rapidly than neutralizing antibodies. The adjuvants Arlacel A and Bayol F, when mixed with vaccine, resulted in the maintenance of high complement fixing antibody titers for longer periods (up to 6 months).
No anamnestic complement fixing antibody response occurred in immune mice revaccinated with heterotypic strains, in contrast to previous findings in man and chimpanzees.
Following vaccination of adult mice with infected torsos of infant mice, an antibody developed which fixed complement with antigen prepared from torsos (chiefly muscle and bone) of normal infant mice. The antibody was stable at 56 C for 30 minutes, but was inactivated at 60 C for 20 minutes. The normal tissue antigen could be removed from suspensions by precipitation with protamine.
Footnotes
- Received November 21, 1952.
- Copyright © 1953 by The American Association of Immunologists, Inc.
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