Summary
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1. The effect of the presence of complement in normal rabbit sera on both the antigen and antibody precipitation behavior in the region of antigen excess has been shown.
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2. It has been postulated that rabbit complement causes some of the soluble antigen-antibody complexes to become insoluble, thus shifting the equilibria existing in the region of antigen excess.
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3. Only 60% of the complement nitrogen was removed by 100 μgN of an Ea-anti Ea specific precipitate per ml of serum.
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4. The precipitin curves obtained in the presence of 0.85% saline and 5% serum albumin are similar.
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5. The degree of iodination of gamma globulin molecules and antibody molecules (anti BSA) is fairly similar.
Footnotes
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↵1 This work was supported by Atomic Energy Commission contract No. AT(30-1)-1205.
- Received December 22, 1952.
- Copyright © 1953 by The American Association of Immunologists, Inc.
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