Summary
The ratio between the homologous in ovo neutralization and hemagglutination-inhibition titers of rooster antisera against influenza A virus strains varies widely. The hemagglutination-inhibition technique yields, in cross-serological experiments, somewhat less evidence of an antigenic difference between strains than does the in ovo neutralization procedure. Analysis of the antigenic relation between 2 strains by means of antiserum against 1 of the strains (r value analysis) may yield very misleading results, particularly if the hemagglutination-inhibition procedure is employed. Similar analysis by means of antisera against both strains (R value analysis) shows good correlation between the results obtained by hemagglutination-inhibition and by in ovo neutralization.
The results of complete cross-serological experiments carried out both by the in vivo and the in vitro procedures indicate that influenza A virus strains may show alteration in antigenic composition during successive annual epidemics. They indicate, also, that there is little evidence of antigenic difference between strains recovered in various parts of the world during 1951.
- Received May 12, 1952.
- Copyright © 1952 by The American Association of Immunologists, Inc.
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