Summary
-
1. Dermal sensitivity was not induced in guinea pigs by repeated intradermal injections of brucellergen, brucellin, or a Brucella vaccine containing 200,000,000 dead cells per ml.
-
2. Repeated intraperitoneal injections of guinea pigs with brucellergen or brucellin failed to stimulate a significant production of either agglutinins or complement fixing antibodies. Brucella vaccine, however, prepared from dead cells was antigenic when administered intraperitoneally and caused significant antibody formation.
-
3. The quantity of each agent required to cause production of serum antibody is many fold the amount used in successive intradermal tests. The order of increasing antigenicity of the Brucella preparations tested was: brucellergen, brucellin, and Brucella vaccine.
-
4. The data obtained from guinea pigs indicate that repeated intradermal tests with brucellergen will not sensitize patients to protein nucleates derived from Brucella.
Footnotes
-
↵1 The authors are appreciative of the technical assistance of Vera Crawford and Mary Dolch.
-
↵2 Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.
- Received April 24, 1952.
- Copyright © 1952 by The American Association of Immunologists, Inc.
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
Log in using your username and password
In this issue
