Summary
Twenty-eight out of 180 compounds tested prevented lysis of Escherichia coli B by T2r+ bacteriophage. Possible mechanisms of their activity are presented. Inhibition by many of these compounds was reversed by one or more naturally occurring substances, particularly those associated with oxidative enzyme systems. Quinacrine was antagonized competitively by riboflavin and nicotinic acid, and non-competitively by thiamin. Phthalic acid was reversed non-competitively by thiamin, cysteine and creatinine. Inhibition induced by streptomycin was reversed competitively by pyridoxine and non-competitively by p-aminobenzoic acid.
Footnotes
- Received January 11, 1952.
- Copyright © 1952 by The American Association of Immunologists, Inc.
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